Case Reports: Emery-Dreifuss Muscular Dystrophy Presenting as a Heart Rhythm Disorders in Children.

EMD (emerin) Emery-Dreifuss muscular dystrophy LMNA atrial fibrillation atrial tachycardia cardiomyopathy children pacemaker implantation

Journal

Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388

Informations de publication

Date de publication:
2021
Historique:
received: 15 02 2021
accepted: 07 04 2021
entrez: 24 5 2021
pubmed: 25 5 2021
medline: 25 5 2021
Statut: epublish

Résumé

Emery-Dreifuss muscular dystrophy (EDMD) is inherited muscle dystrophy often accompanied by cardiac abnormalities in the form of supraventricular arrhythmias, conduction defects and sinus node dysfunction. Cardiac phenotype typically arises years after skeletal muscle presentation, though, could be severe and life-threatening. The defined clinical manifestation with joint contractures, progressive muscle weakness and atrophy, as well as cardiac symptoms are observed by the third decade of life. Still, clinical course and sequence of muscle and cardiac signs may be variable and depends on the genotype. Cardiac abnormalities in patients with EDMD in pediatric age are not commonly seen. Here we describe five patients with different forms of EDMD (X-linked and autosomal-dominant) caused by the mutations in

Identifiants

pubmed: 34026875
doi: 10.3389/fcvm.2021.668231
pmc: PMC8137911
doi:

Types de publication

Case Reports

Langues

eng

Pagination

668231

Informations de copyright

Copyright © 2021 Kovalchuk, Yakovleva, Fetisova, Vershinina, Lebedeva, Lyubimtseva, Lebedev, Mitrofanova, Ryzhkov, Sokolnikova, Fomicheva, Kozyreva, Zhuk, Smolina, Zlotina, Pervunina, Kostareva and Vasichkina.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Tatiana Kovalchuk (T)

World-Class Research Centre for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Elena Yakovleva (E)

World-Class Research Centre for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Svetlana Fetisova (S)

World-Class Research Centre for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Tatiana Vershinina (T)

World-Class Research Centre for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Viktoriya Lebedeva (V)

Institute of Heart and Vessels, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Tamara Lyubimtseva (T)

Institute of Heart and Vessels, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Dmitriy Lebedev (D)

Institute of Heart and Vessels, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Lubov Mitrofanova (L)

Pathology Unit, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Anton Ryzhkov (A)

Radiology Unit, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Polina Sokolnikova (P)

Institute of Molecular biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Yuliya Fomicheva (Y)

Institute of Molecular biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Alexandra Kozyreva (A)

Institute of Molecular biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Sergey Zhuk (S)

Institute of Molecular biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Natalia Smolina (N)

Institute of Molecular biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Anna Zlotina (A)

Institute of Molecular biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Tatiana Pervunina (T)

Institute of Perinatology and Pediatrics, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Anna Kostareva (A)

Institute of Molecular biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Department of Women's and Children's Health and Center for Molecular Medicine, Karolinska Institutet, Solna, Sweden.

Elena Vasichkina (E)

World-Class Research Centre for Personalized Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia.

Classifications MeSH