Altered connectivity of the default mode network in cognitively stable adults with Down syndrome: "Accelerated aging" or a prelude to Alzheimer's disease?
Alzheimer's disease
Down syndrome
altered functional connectivity
default mode network
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
05
2020
revised:
18
08
2020
accepted:
19
08
2020
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
25
5
2021
Statut:
epublish
Résumé
Most individuals with Down syndrome (DS) have the neuropathological changes of Alzheimer's disease (AD) by age 40 and will have developed dementia by age 60. Alterations of the intrinsic connectivity of the default mode network (DMN) are associated with AD in the neurotypical population. In this study, we sought to determine whether, and how, connectivity between the hubs of the DMN were altered in cognitively stable adults with DS who did not have evidence of either mild cognitive impairment or AD. Resting state functional MRI scans were collected from 26 healthy adults with DS and 26 healthy age-matched non-DS controls. Nodes comprising the DMN were generated as ROI's (regions of interest) and inter-nodal correlations estimated. Analysis of intra-network connectivity of the DMN revealed anterior-posterior DMN dissociation and hyper- and hypo-connectivity, suggesting "accelerated aging" in DS. Disruption of the DMN may serve as a prelude for AD in DS.
Identifiants
pubmed: 34027014
doi: 10.1002/dad2.12105
pii: DAD212105
pmc: PMC8136300
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12105Subventions
Organisme : NIA NIH HHS
ID : U19 AG068054
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest.
Références
Am J Ment Retard. 2004 Mar;109(2):111-25
pubmed: 15000666
Acta Neuropathol. 2012 Jan;123(1):13-30
pubmed: 22101321
J Intellect Disabil Res. 2000 Apr;44 ( Pt 2):175-80
pubmed: 10898382
Ann N Y Acad Sci. 2014 May;1316:29-52
pubmed: 24502540
Biol Psychiatry. 2013 Sep 1;74(5):340-7
pubmed: 23290495
Neurobiol Aging. 2017 Jun;54:163-169
pubmed: 28385551
J Intellect Disabil Res. 1997 Feb;41 ( Pt 1):92-6
pubmed: 9089465
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7209-14
pubmed: 19357304
J Cogn Neurosci. 2006 Feb;18(2):227-41
pubmed: 16494683
J Lipid Res. 1990 Mar;31(3):545-8
pubmed: 2341813
Neurology. 2013 Nov 12;81(20):1732-40
pubmed: 24132377
Bioessays. 2015 Jun;37(6):624-32
pubmed: 25773221
Aging Cell. 2015 Jun;14(3):491-5
pubmed: 25678027
Br J Psychiatry. 2002 May;180:405-10
pubmed: 11983636
Alzheimers Dement. 2016 May;12(5):538-45
pubmed: 26362596
Brain. 2016 Feb;139(Pt 2):547-62
pubmed: 26586695
Hum Brain Mapp. 2019 Oct 15;40(15):4551-4563
pubmed: 31350817
J Neurosci. 2005 Aug 24;25(34):7709-17
pubmed: 16120771
Neuroimage Clin. 2013 May 24;2:703-15
pubmed: 24179822
PLoS One. 2013 Aug 28;8(8):e74070
pubmed: 24015315
Brain Connect. 2015 Oct;5(8):461-75
pubmed: 25712025
Alzheimers Dement. 2016 Apr;12(4):380-90
pubmed: 26079411
Neuroimage. 2018 May 1;171:6-14
pubmed: 29288131
Alzheimers Dement. 2010 Jul;6(4):303-11
pubmed: 19744893
Subcell Biochem. 2019;91:161-193
pubmed: 30888653
J Neurosci. 2012 Jun 27;32(26):8890-9
pubmed: 22745490
Ann N Y Acad Sci. 1986;477:247-60
pubmed: 2949682
Int Rev Res Ment Retard. 2008 Jan 1;36:103-145
pubmed: 19633729
Nat Rev Dis Primers. 2020 Feb 6;6(1):9
pubmed: 32029743
Alzheimers Dement. 2012 Nov;8(6):496-501
pubmed: 23102120
J Alzheimers Dis. 2015;43(3):1073-90
pubmed: 25147118
Neurology. 2010 Nov 2;75(18):1639-44
pubmed: 21041786
Cereb Cortex. 2010 Jun;20(6):1432-47
pubmed: 19789183
Neuroimage. 2015 Jan 15;105:536-51
pubmed: 25462692
Birth Defects Res A Clin Mol Teratol. 2010 Dec;88(12):1008-16
pubmed: 20878909
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Arch Neurol. 1989 Aug;46(8):849-53
pubmed: 2527024
Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4637-42
pubmed: 15070770
Psychiatry Res. 1997 May 16;74(2):73-82
pubmed: 9204510
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
Nat Rev Neurosci. 2019 Oct;20(10):593-608
pubmed: 31492945