A Western-style dietary pattern is associated with cerebrospinal fluid biomarker levels for preclinical Alzheimer's disease-A population-based cross-sectional study among 70-year-olds.
Alzheimer's disease
amyloid
biomarkers
diet
dietary patterns
tau
Journal
Alzheimer's & dementia (New York, N. Y.)
ISSN: 2352-8737
Titre abrégé: Alzheimers Dement (N Y)
Pays: United States
ID NLM: 101650118
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
09
2020
revised:
17
03
2021
accepted:
20
04
2021
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
25
5
2021
Statut:
epublish
Résumé
Diet may be a modifiable factor for reducing the risk of Alzheimer's disease (AD). Western-style dietary patterns are considered to increase the risk, whereas Mediterranean-style dietary patterns are considered to reduce the risk. An association between diet and AD-related biomarkers have been suggested, but studies are limited. To investigate potential relations between dietary patterns and cerebrospinal fluid (CSF) biomarkers for AD among dementia-free older adults. Data were derived from the population-based Gothenburg H70 Birth Cohort Studies, Sweden. A total of 269 dementia-free 70-year-olds with dietary and cerebrospinal fluid (CSF) amyloid beta (Aβ42 and Aβ40), total tau (t-tau), and phosphorylated tau (p-tau) data were investigated. Dietary intake was determined by the diet history method, and four dietary patterns were derived by principal component analysis. A Western dietary pattern, a Mediterranean/prudent dietary pattern, a high-protein and alcohol pattern, and a high-total and saturated fat pattern. Logistic regression models, with CSF biomarker pathology (yes/no) as dependent variables, and linear regression models with continuous CSF biomarker levels as dependent variables were performed. The analyses were adjusted for sex, energy intake, body mass index (BMI), educational level, and physical activity level. The odds ratio for having total tau pathology (odds ratio [OR] 1.43; 95% confidence interval [CI] 1.02 to 2.01) and preclinical AD (Aβ42 and tau pathology; OR 1.79; 95% CI 1.03 to 3.10) was higher among those with a higher adherence to a Western dietary pattern. There were no other associations between the dietary patterns and CSF biomarkers that remained significant in both unadjusted and adjusted models. Our findings suggest that higher adherence to a Western dietary pattern may be associated with pathological levels of AD biomarkers in the preclinical phase of AD. These findings can be added to the increasing amount of evidence linking diet with AD and may be useful for future intervention studies investigating dietary intake in relation to AD.
Sections du résumé
BACKGROUND
BACKGROUND
Diet may be a modifiable factor for reducing the risk of Alzheimer's disease (AD). Western-style dietary patterns are considered to increase the risk, whereas Mediterranean-style dietary patterns are considered to reduce the risk. An association between diet and AD-related biomarkers have been suggested, but studies are limited.
AIM
OBJECTIVE
To investigate potential relations between dietary patterns and cerebrospinal fluid (CSF) biomarkers for AD among dementia-free older adults.
METHODS
METHODS
Data were derived from the population-based Gothenburg H70 Birth Cohort Studies, Sweden. A total of 269 dementia-free 70-year-olds with dietary and cerebrospinal fluid (CSF) amyloid beta (Aβ42 and Aβ40), total tau (t-tau), and phosphorylated tau (p-tau) data were investigated. Dietary intake was determined by the diet history method, and four dietary patterns were derived by principal component analysis. A Western dietary pattern, a Mediterranean/prudent dietary pattern, a high-protein and alcohol pattern, and a high-total and saturated fat pattern. Logistic regression models, with CSF biomarker pathology (yes/no) as dependent variables, and linear regression models with continuous CSF biomarker levels as dependent variables were performed. The analyses were adjusted for sex, energy intake, body mass index (BMI), educational level, and physical activity level.
RESULTS
RESULTS
The odds ratio for having total tau pathology (odds ratio [OR] 1.43; 95% confidence interval [CI] 1.02 to 2.01) and preclinical AD (Aβ42 and tau pathology; OR 1.79; 95% CI 1.03 to 3.10) was higher among those with a higher adherence to a Western dietary pattern. There were no other associations between the dietary patterns and CSF biomarkers that remained significant in both unadjusted and adjusted models.
DISCUSSION
CONCLUSIONS
Our findings suggest that higher adherence to a Western dietary pattern may be associated with pathological levels of AD biomarkers in the preclinical phase of AD. These findings can be added to the increasing amount of evidence linking diet with AD and may be useful for future intervention studies investigating dietary intake in relation to AD.
Identifiants
pubmed: 34027029
doi: 10.1002/trc2.12183
pii: TRC212183
pmc: PMC8129853
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12183Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
None.
Références
Circulation. 1968 Dec;38(6):1104-15
pubmed: 5721960
Ann N Y Acad Sci. 2016 Mar;1367(1):31-7
pubmed: 27116239
Nutr J. 2019 Nov 6;18(1):66
pubmed: 31694635
Arch Neurol. 2011 Jun;68(6):743-52
pubmed: 21670398
Alzheimers Res Ther. 2019 Jan 5;11(1):1
pubmed: 30611304
Alzheimers Dement. 2015 Sep;11(9):1007-14
pubmed: 25681666
Clin Chem Lab Med. 2018 Nov 27;56(12):2058-2066
pubmed: 29949507
Alzheimers Dement. 2011 May;7(3):280-92
pubmed: 21514248
Am J Clin Nutr. 2017 Dec;106(6):1463-1470
pubmed: 29070566
Lancet Neurol. 2006 Mar;5(3):228-34
pubmed: 16488378
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Lancet Neurol. 2019 Jan;18(1):88-106
pubmed: 30497964
Curr Dev Nutr. 2019 Sep 17;3(10):nzz104
pubmed: 31598577
Int J Behav Nutr Phys Act. 2016 Feb 29;13:30
pubmed: 26928406
Rev Neurol (Paris). 2019 Dec;175(10):724-741
pubmed: 31521398
Am J Geriatr Psychiatry. 2016 Sep;24(9):729-37
pubmed: 27421618
Neurology. 2018 May 15;90(20):e1789-e1798
pubmed: 29653991
Neurosci Lett. 2000 May 5;285(1):49-52
pubmed: 10788705
Adv Nutr. 2016 Sep 15;7(5):889-904
pubmed: 27633105
Lancet Neurol. 2013 Feb;12(2):207-16
pubmed: 23332364
Adv J Mol Imaging. 2014 Oct;4(4):43-57
pubmed: 25599008
Alzheimers Dement (N Y). 2018 Oct 14;4:535-541
pubmed: 30386818
J Alzheimers Dis. 2018;64(1):281-290
pubmed: 29889074
Curr Nutr Rep. 2019 Jun;8(2):53-65
pubmed: 30949921
Transl Psychiatry. 2018 Oct 30;8(1):238
pubmed: 30375373
Alzheimers Dement. 2016 Mar;12(3):292-323
pubmed: 27012484
J Mol Neurosci. 2017 Mar;61(3):289-304
pubmed: 27864661
Eur J Epidemiol. 2019 Feb;34(2):191-209
pubmed: 30421322
Acta Med Scand. 1975 Nov;198(5):397-407
pubmed: 1081814
Adv Nutr. 2017 Sep 15;8(5):652-678
pubmed: 28916567
Neurobiol Aging. 2019 Apr;76:45-52
pubmed: 30682676
J Alzheimers Dis. 2015;50(2):301-34
pubmed: 26682690
Lancet. 2020 Aug 8;396(10248):413-446
pubmed: 32738937
JAMA Neurol. 2014 Apr;71(4):505-8
pubmed: 24493463
Ann Am Thorac Soc. 2019 Jan;16(1):22-28
pubmed: 30230362
BMJ Open. 2014 Jun 24;4(6):e004850
pubmed: 24961717
Front Aging Neurosci. 2015 Oct 23;7:199
pubmed: 26557086
J Prev Alzheimers Dis. 2018;5(2):137-141
pubmed: 29616707
J Alzheimers Dis. 2014;42(3):823-31
pubmed: 24934544
Lancet. 2006 Jul 29;368(9533):387-403
pubmed: 16876668
J Am Diet Assoc. 2010 Jun;110(6):911-16.e12
pubmed: 20497781
BMC Public Health. 2012 Aug 24;12:693
pubmed: 22920914
J Intern Med. 2018 Dec;284(6):643-663
pubmed: 30051512
Neurology. 2018 May 8;90(19):e1682-e1691
pubmed: 29653987
Alzheimers Dement. 2016 Feb;12(2):100-109
pubmed: 26342761
J Nutr Health Aging. 2015 Apr;19(4):413-23
pubmed: 25809805
Neurol Sci. 2019 Oct;40(10):2031-2043
pubmed: 31240575
Alzheimers Res Ther. 2019 Apr 22;11(1):34
pubmed: 31010420
Neurosci Lett. 2003 Nov 27;352(1):67-9
pubmed: 14615052
Neurology. 2019 Mar 19;92(12):e1322-e1330
pubmed: 30787164
Nat Rev Neurol. 2018 Nov;14(11):653-666
pubmed: 30291317
J Alzheimers Dis. 2017;59(3):815-849
pubmed: 28697569
Neurology. 2016 Aug 2;87(5):539-47
pubmed: 27371494