The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate.
SIRT7
nucleolus
nucleophosmin
p53
ultraviolet irradiation
Journal
Molecular & cellular oncology
ISSN: 2372-3556
Titre abrégé: Mol Cell Oncol
Pays: United States
ID NLM: 101642411
Informations de publication
Date de publication:
31 Mar 2021
31 Mar 2021
Historique:
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
25
5
2021
Statut:
epublish
Résumé
Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that sirtuin 7 (SIRT7) activates this pathway by directly deacetylating NPM following ultraviolet irradiation, indicating tumor-suppressive functions of SIRT7.
Identifiants
pubmed: 34027038
doi: 10.1080/23723556.2021.1896349
pii: 1896349
pmc: PMC8128210
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1896349Informations de copyright
© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.
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