The role of comorbidities on mortality of COVID-19 in patients with diabetes.
COVID-19
Diabetes mellitus
Kidney disease
Liver disease
Mortality
Journal
Obesity medicine
ISSN: 2451-8476
Titre abrégé: Obes Med
Pays: England
ID NLM: 101690300
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
13
03
2021
revised:
11
05
2021
accepted:
12
05
2021
pubmed:
25
5
2021
medline:
25
5
2021
entrez:
24
5
2021
Statut:
ppublish
Résumé
Patients with diabetes are one of the most high-risk group to become infected with SARS-CoV-2 In this cross-sectional study (25 February to July 10, 2020), 458 patients with diabetes were enrolled based on their characteristics, symptoms and signs, laboratory data and presence of other underlying diseases. Multiple logistic regression and Chi-square test analysis were used to check the effectiveness of other comorbidities on the mortality outcome among patients with diabetes. Of 458 patients with diabetes, 306 (67%) had other underlying diseases, such as 200 (65.4%) hypertension, 103 (33.7%) cardiovascular diseases and 29 (9.5%) kidney diseases. The rate of fatality was significantly high in patients with chronic kidney and liver diseases. The odds of mortality were increased 3.1-fold for patients over 55 years as compared to those under 55 years (P = 0.011), and the odds of mortality outcome were more than 5.1-fold for those who had chronic kidney disease (P < 0.001). The presentation of SARS-CoV-2 in older patients with diabetes with other comorbidities such as chronic kidney and liver diseases is more severe in risk of mortality.
Sections du résumé
BACKGROUND
BACKGROUND
Patients with diabetes are one of the most high-risk group to become infected with SARS-CoV-2
METHODS
METHODS
In this cross-sectional study (25 February to July 10, 2020), 458 patients with diabetes were enrolled based on their characteristics, symptoms and signs, laboratory data and presence of other underlying diseases. Multiple logistic regression and Chi-square test analysis were used to check the effectiveness of other comorbidities on the mortality outcome among patients with diabetes.
RESULTS
RESULTS
Of 458 patients with diabetes, 306 (67%) had other underlying diseases, such as 200 (65.4%) hypertension, 103 (33.7%) cardiovascular diseases and 29 (9.5%) kidney diseases. The rate of fatality was significantly high in patients with chronic kidney and liver diseases. The odds of mortality were increased 3.1-fold for patients over 55 years as compared to those under 55 years (P = 0.011), and the odds of mortality outcome were more than 5.1-fold for those who had chronic kidney disease (P < 0.001).
CONCLUSIONS
CONCLUSIONS
The presentation of SARS-CoV-2 in older patients with diabetes with other comorbidities such as chronic kidney and liver diseases is more severe in risk of mortality.
Identifiants
pubmed: 34027220
doi: 10.1016/j.obmed.2021.100352
pii: S2451-8476(21)00035-X
pmc: PMC8123934
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100352Informations de copyright
© 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
No conflict of interest.