Sirtuins as molecular targets, mediators, and protective agents in metal-induced toxicity.
Antioxidants
Apoptosis
Inflammation
Metals
Mitochondrial biogenesis
Sirtuin
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
26
02
2021
accepted:
01
04
2021
pubmed:
25
5
2021
medline:
5
4
2022
entrez:
24
5
2021
Statut:
ppublish
Résumé
Metal dyshomeostasis, and especially overexposure, is known to cause adverse health effects due to modulation of a variety of metabolic pathways. An increasing body of literature has demonstrated that metal exposure may affect SIRT signaling, although the existing data are insufficient. Therefore, in this review we discuss the available data (PubMed-Medline, Google Scholar) on the influence of metal overload on sirtuin (SIRT) signaling and its association with other mechanisms involved in metal-induced toxicity. The existing data demonstrate that cadmium (Cd), mercury (Hg), arsenic (As), lead (Pb), aluminium (Al), hexavalent chromium (Cr
Identifiants
pubmed: 34028595
doi: 10.1007/s00204-021-03048-6
pii: 10.1007/s00204-021-03048-6
doi:
Substances chimiques
Metals, Heavy
0
Protective Agents
0
Cadmium
00BH33GNGH
Sirtuins
EC 3.5.1.-
Mercury
FXS1BY2PGL
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2263-2278Subventions
Organisme : National Institute of Environmental Health Sciences (US)
ID : R01ES10563
Organisme : NIEHS NIH HHS
ID : R01ES07331
Pays : United States
Références
Abdullah A, Mohd Murshid N, Makpol S (2020) Antioxidant modulation of mTOR and sirtuin pathways in age-related neurodegenerative diseases. Mol Neurobiol 57(12):5193–5207. https://doi.org/10.1007/s12035-020-02083-1
doi: 10.1007/s12035-020-02083-1
pubmed: 32865663
Baker ZN, Cobine PA, Leary SC (2017) The mitochondrion: a central architect of copper homeostasis. Metallomics 9(11):1501–1512. https://doi.org/10.1039/c7mt00221a
doi: 10.1039/c7mt00221a
pubmed: 28952650
pmcid: 5688007
Bannon DI, Bao W, Turner SD, McCain WC, Dennis W, Wolfinger R, Perkins E, Abounader R (2020) Gene expression in mouse muscle over time after nickel pellet implantation. Metallomics 12(4):528–538. https://doi.org/10.1039/c9mt00289h
doi: 10.1039/c9mt00289h
pubmed: 32065191
Beauharnois JM, Bolívar BE, Welch JT (2013) Sirtuin 6: a review of biological effects and potential therapeutic properties. Mol Biosyst 9(7):1789–1806. https://doi.org/10.1039/c3mb00001j
doi: 10.1039/c3mb00001j
pubmed: 23592245
Bheda P, Jing H, Wolberger C, Lin H (2016) The substrate specificity of sirtuins. Annu Rev Biochem 85:405–429. https://doi.org/10.1146/annurev-biochem-060815-014537
doi: 10.1146/annurev-biochem-060815-014537
pubmed: 27088879
Blank MF, Grummt I (2017) The seven faces of SIRT7. Transcription 8(2):67–74. https://doi.org/10.1080/21541264.2016.1276658
doi: 10.1080/21541264.2016.1276658
pubmed: 28067587
pmcid: 5423475
Bornhorst J, Ebert F, Lohren H, Humpf HU, Karst U, Schwerdtle T (2012) Effects of manganese and arsenic species on the level of energy related nucleotides in human cells. Metallomics 4(3):297–306. https://doi.org/10.1039/c2mt00164k
doi: 10.1039/c2mt00164k
pubmed: 22266671
Boutant M, Cantó C (2016) SIRT1 in metabolic health and disease. In: Houtkooper R (ed) Sirtuins. Proteins and cell regulation, vol 10. Springer, Dordrecht, pp 71–104
Cai AL, Zipfel GJ, Sheline CT (2006) Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway. Eur J Neurosci 24(8):2169–2176. https://doi.org/10.1111/j.1460-9568.2006.05110.x
doi: 10.1111/j.1460-9568.2006.05110.x
pubmed: 17042794
Carafa V, Rotili D, Forgione M, Cuomo F, Serretiello E, Hailu GS, Jarho E, Lahtela-Kakkonen M, Mai A, Altucci L (2016) Sirtuin functions and modulation: from chemistry to the clinic. Clin Epigenet 8:61. https://doi.org/10.1186/s13148-016-0224-3
doi: 10.1186/s13148-016-0224-3
Chen L, Feng Y, Zhou Y, Zhu W, Shen X, Chen K, Jiang H, Liu D (2010) Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1. J Inorg Biochem 104(2):180–185. https://doi.org/10.1016/j.jinorgbio.2009.10.021
doi: 10.1016/j.jinorgbio.2009.10.021
pubmed: 19923004
Chen B, Zang W, Wang J, Huang Y, He Y, Yan L, Liu J, Zheng W (2015) The chemical biology of sirtuins. Chem Soc Rev 44(15):5246–5264. https://doi.org/10.1039/c4cs00373j
doi: 10.1039/c4cs00373j
pubmed: 25955411
Chen F, Zhou CC, Yang Y, Liu JW, Yan CH (2019) GM1 ameliorates lead-induced cognitive deficits and brain damage through activating the SIRT1/CREB/BDNF pathway in the developing male rat hippocampus. Biol Trace Elem Res 190(2):425–436. https://doi.org/10.1007/s12011-018-1569-6
doi: 10.1007/s12011-018-1569-6
pubmed: 30414004
Chou X, Ding F, Zhang X, Ding X, Gao H, Wu Q (2019) Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells. Arch Toxicol 93(4):965–986. https://doi.org/10.1007/s00204-019-02415-8
doi: 10.1007/s00204-019-02415-8
pubmed: 30796460
Clementino M, Kim D, Zhang Z (2019) Constitutive activation of NAD-dependent sirtuin 3 plays an important role in tumorigenesis of chromium(VI)-transformed cells. Toxicol Sci 169(1):224–234. https://doi.org/10.1093/toxsci/kfz032
doi: 10.1093/toxsci/kfz032
pubmed: 30715550
pmcid: 6484885
Dai H, Sinclair DA, Ellis JL, Steegborn C (2018) Sirtuin activators and inhibitors: promises, achievements, and challenges. Pharmacol Ther 188:140–154. https://doi.org/10.1016/j.pharmthera.2018.03.004
doi: 10.1016/j.pharmthera.2018.03.004
pubmed: 29577959
pmcid: 6342514
Das SK, Wang W, Zhabyeyev P, Basu R, McLean B, Fan D, Parajuli N, DesAulniers J, Patel VB, Hajjar RJ, Dyck JR, Kassiri Z, Oudit GY (2015) Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy. Sci Rep 5:18132. https://doi.org/10.1038/srep18132
doi: 10.1038/srep18132
pubmed: 26638758
pmcid: 4671148
Das SK, DesAulniers J, Dyck JR, Kassiri Z, Oudit GY (2016) Resveratrol mediates therapeutic hepatic effects in acquired and genetic murine models of iron-overload. Liver Int 36(2):246–257. https://doi.org/10.1111/liv.12893
doi: 10.1111/liv.12893
pubmed: 26077449
Dogra S, Kar AK, Girdhar K, Daniel PV, Chatterjee S, Choubey A, Ghosh S, Patnaik S, Ghosh D, Mondal P (2019) Zinc oxide nanoparticles attenuate hepatic steatosis development in high-fat-diet fed mice through activated AMPK signaling axis. Nanomedicine 17:210–222. https://doi.org/10.1016/j.nano.2019.01.013
doi: 10.1016/j.nano.2019.01.013
pubmed: 30708053
Doumandji Z, Safar R, Lovera-Leroux M, Nahle S, Cassidy H, Matallanas D, Rihn B, Ferrari L, Joubert O (2020) Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles. Cell Biol Toxicol 36(1):65–82. https://doi.org/10.1007/s10565-019-09484-6
doi: 10.1007/s10565-019-09484-6
pubmed: 31352547
Du X, Tian M, Wang X, Zhang J, Huang Q, Liu L, Shen H (2018) Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water. Environ Pollut 234:590–600. https://doi.org/10.1016/j.envpol.2017.11.083
doi: 10.1016/j.envpol.2017.11.083
pubmed: 29223816
Duan WX, He MD, Mao L, Qian FH, Li YM, Pi HF, Liu C, Chen CH, Lu YH, Cao ZW, Zhang L, Yu ZP, Zhou Z (2015) NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells. Toxicol Appl Pharmacol 286(2):80–91. https://doi.org/10.1016/j.taap.2015.03.024
doi: 10.1016/j.taap.2015.03.024
pubmed: 25840356
El-Kott AF, Abd-Lateif AM, Khalifa HS, Morsy K, Ibrahim EH, Bin-Jumah M, Abdel-Daim MM, Aleya L (2020) Kaempferol protects against cadmium chloride-induced hippocampal damage and memory deficits by activation of silent information regulator 1 and inhibition of poly (ADP-Ribose) polymerase-1. Sci Total Environ 728:138832. https://doi.org/10.1016/j.scitotenv.2020.138832
doi: 10.1016/j.scitotenv.2020.138832
pubmed: 32353801
Exil V, Ping L, Yu Y, Chakraborty S, Caito SW, Wells KS, Karki P, Lee E, Aschner M (2014) Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures. PLoS ONE 9(5):e94753. https://doi.org/10.1371/journal.pone.0094753
doi: 10.1371/journal.pone.0094753
pubmed: 24787138
pmcid: 4008430
Feng C, Gu J, Zhou F, Li J, Zhu G, Guan L, Liu H, Du G, Feng J, Liu D, Zhang S, Fan G (2016) The effect of lead exposure on expression of SIRT1 in the rat hippocampus. Environ Toxicol Pharmacol 44:84–92. https://doi.org/10.1016/j.etap.2016.04.008
doi: 10.1016/j.etap.2016.04.008
pubmed: 27131751
Fu B, Zhao J, Peng W, Wu H, Zhang Y (2017) Resveratrol rescues cadmium-induced mitochondrial injury by enhancing transcriptional regulation of PGC-1α and SOD2 via the Sirt3/FoxO3a pathway in TCMK-1 cells. Biochem Biophys Res Commun 486(1):198–204. https://doi.org/10.1016/j.bbrc.2017.03.027
doi: 10.1016/j.bbrc.2017.03.027
pubmed: 28286268
Gao X, Zhang C, Zheng P, Dan Q, Luo H, Ma X, Lu C (2020) Arsenic suppresses GDF1 expression via ROS-dependent downregulation of specificity protein 1. Environ Pollut 271:116302
doi: 10.1016/j.envpol.2020.116302
Guo P, Pi H, Xu S, Zhang L, Li Y, Li M, Cao Z, Tian L, Xie J, Li R, He M, Lu Y, Liu C, Duan W, Yu Z, Zhou Z (2014) Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro. Toxicol Sci 142(1):182–195. https://doi.org/10.1093/toxsci/kfu164
doi: 10.1093/toxsci/kfu164
pubmed: 25159133
pmcid: 4226765
Han B, Li S, Lv Y, Yang D, Li J, Yang Q, Wu P, Lv Z, Zhang Z (2019) Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/Pgc-1α/Nrf2 pathway. Food Funct 10(9):5555–5565. https://doi.org/10.1039/c9fo01152h
doi: 10.1039/c9fo01152h
pubmed: 31429458
Han D, Jiang L, Gu X, Huang S, Pang J, Wu Y, Yin J, Wang J (2020) SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels. J Cell Physiol 235(11):8839–8851. https://doi.org/10.1002/jcp.29727
doi: 10.1002/jcp.29727
pubmed: 32329068
Hanagata N, Zhuang F, Connolly S, Li J, Ogawa N, Xu M (2011) Molecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis. ACS Nano 5(12):9326–9338. https://doi.org/10.1021/nn202966t
doi: 10.1021/nn202966t
pubmed: 22077320
Hao R, Song X, Li F, Tan X, Sun-Waterhouse D, Li D (2020) Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: Involvements of AMPK/SIRT1 pathway and amyloid-tau-neuroinflammation axis. Food Chem Toxicol 144:111636. https://doi.org/10.1016/j.fct.2020.111636
doi: 10.1016/j.fct.2020.111636
pubmed: 32739455
He X, Gao J, Hou H, Qi Z, Chen H, Zhang XX (2019) Inhibition of mitochondrial fatty acid oxidation contributes to development of nonalcoholic fatty liver disease induced by environmental cadmium exposure. Environ Sci Technol 53(23):13992–14000. https://doi.org/10.1021/acs.est.9b05131
doi: 10.1021/acs.est.9b05131
pubmed: 31682409
Herbert KJ, Holloway A, Cook AL, Chin SP, Snow ET (2014) Arsenic exposure disrupts epigenetic regulation of SIRT1 in human keratinocytes. Toxicol Appl Pharmacol 281(1):136–145. https://doi.org/10.1016/j.taap.2014.09.012
doi: 10.1016/j.taap.2014.09.012
pubmed: 25281835
Iwahara T, Bonasio R, Narendra V, Reinberg D (2012) SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol 32(24):5022–5034. https://doi.org/10.1128/MCB.00822-12
doi: 10.1128/MCB.00822-12
pubmed: 23045395
pmcid: 3510539
Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN (2014) Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol 7(2):60–72. https://doi.org/10.2478/intox-2014-0009
doi: 10.2478/intox-2014-0009
pubmed: 26109881
pmcid: 4427717
Javadipour M, Rezaei M, Keshtzar E, Khodayar MJ (2019) Metformin in contrast to berberine reversed arsenic-induced oxidative stress in mitochondria from rat pancreas probably via Sirt3-dependent pathway. J Biochem Mol Toxicol 33(9):e22368. https://doi.org/10.1002/jbt.22368
doi: 10.1002/jbt.22368
pubmed: 31332900
Jebbett NJ, Hamilton JW, Rand MD, Eckenstein F (2013) Low level methylmercury enhances CNTF-evoked STAT3 signaling and glial differentiation in cultured cortical progenitor cells. Neurotoxicology 38:91–100. https://doi.org/10.1016/j.neuro.2013.06.008
doi: 10.1016/j.neuro.2013.06.008
pubmed: 23845766
pmcid: 3802548
Jeong SM, Lee J, Finley LW, Schmidt PJ, Fleming MD, Haigis MC (2015) SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. Oncogene 34(16):2115–2124. https://doi.org/10.1038/onc.2014.124
doi: 10.1038/onc.2014.124
pubmed: 24909164
Kane AE, Sinclair DA (2018) Sirtuins and NAD+ in the development and treatment of metabolic and cardiovascular diseases. Circ Res 123(7):868–885. https://doi.org/10.1161/CIRCRESAHA.118.312498
doi: 10.1161/CIRCRESAHA.118.312498
pubmed: 30355082
pmcid: 6206880
Kitada M, Ogura Y, Monno I, Koya D (2019) Sirtuins and type 2 diabetes: role in inflammation, oxidative stress, and mitochondrial function. Front Endocrinol (Lausanne) 10:187. https://doi.org/10.3389/fendo.2019.00187
doi: 10.3389/fendo.2019.00187
Kumar S, Lombard DB (2018) Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology. Crit Rev Biochem Mol Biol 53(3):311–334. https://doi.org/10.1080/10409238.2018.1458071
doi: 10.1080/10409238.2018.1458071
pubmed: 29637793
pmcid: 6233320
Kupis W, Pałyga J, Tomal E, Niewiadomska E (2016) The role of sirtuins in cellular homeostasis. J Physiol Biochem 72(3):371–380. https://doi.org/10.1007/s13105-016-0492-6
doi: 10.1007/s13105-016-0492-6
pubmed: 27154583
pmcid: 4992043
Laudati G, Mascolo L, Guida N, Sirabella R, Pizzorusso V, Bruzzaniti S, Serani A, Di Renzo G, Canzoniero LMT, Formisano L (2019) Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to thimerosal toxicity through SIRT1/DREAM/PDYN pathway. Neurotoxicology 71:6–15. https://doi.org/10.1016/j.neuro.2018.11.009
doi: 10.1016/j.neuro.2018.11.009
pubmed: 30503815
Lee YS, Lee EK, Oh HH, Choi CS, Kim S, Jun HS (2014) Sodium meta-arsenite ameliorates hyperglycemia in obese diabetic db/db mice by inhibition of hepatic gluconeogenesis. J Diabetes Res. https://doi.org/10.1155/2014/961732
doi: 10.1155/2014/961732
pubmed: 25610880
pmcid: 4290036
Lee IC, Ho XY, George SE, Goh CW, Sundaram JR, Pang KKL, Luo W, Yusoff P, Sze NSK, Shenolikar S (2018) Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function. Cell Death Differ 25(2):255–267. https://doi.org/10.1038/cdd.2017.152
doi: 10.1038/cdd.2017.152
pubmed: 28984870
Lee SH, Lee JH, Lee HY, Min KJ (2019) Sirtuin signaling in cellular senescence and aging. BMB Rep 52(1):24–34. https://doi.org/10.5483/BMBRep.2019.52.1.290
doi: 10.5483/BMBRep.2019.52.1.290
pubmed: 30526767
pmcid: 6386230
Li Z, Liu X, Wang L, Wang Y, Du C, Xu S, Zhang Y, Wang C, Yang C (2016) The role of PGC-1α and MRP1 in lead-induced mitochondrial toxicity in testicular sertoli cells. Toxicology 355–356:39–48. https://doi.org/10.1016/j.tox.2016.05.016
doi: 10.1016/j.tox.2016.05.016
pubmed: 27236077
Li S, Baiyun R, Lv Z, Li J, Han D, Zhao W, Yu L, Deng N, Liu Z, Zhang Z (2019a) Exploring the kidney hazard of exposure to mercuric chloride in mice: disorder of mitochondrial dynamics induces oxidative stress and results in apoptosis. Chemosphere 234:822–829. https://doi.org/10.1016/j.chemosphere.2019.06.096
doi: 10.1016/j.chemosphere.2019.06.096
pubmed: 31247492
Li S, Jiang X, Luo Y, Zhou B, Shi M, Liu F, Sha A (2019b) Sodium/calcium overload and Sirt1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity. Chemosphere 234:579–588. https://doi.org/10.1016/j.chemosphere.2019.06.095
doi: 10.1016/j.chemosphere.2019.06.095
pubmed: 31229719
Li D, Liang H, Li Y, Zhang J, Qiao L, Luo H (2021) Allicin alleviates lead-induced bone loss by preventing oxidative stress and osteoclastogenesis via SIRT1/FOXO1 pathway in mice. Biol Trace Elem Res 199(1):237–243. https://doi.org/10.1007/s12011-020-02136-5
doi: 10.1007/s12011-020-02136-5
pubmed: 32314144
Liu X, Ye J, Wang L, Li Z, Zhang Y, Sun J, Du C, Wang C, Xu S (2017) Protective effects of PGC-1α against lead-induced oxidative stress and energy metabolism dysfunction in testis sertoli cells. Biol Trace Elem Res 175(2):440–448. https://doi.org/10.1007/s12011-016-0799-8
doi: 10.1007/s12011-016-0799-8
pubmed: 27392955
Lu J, Huang Q, Zhang D, Lan T, Zhang Y, Tang X, Xu P, Zhao D, Cong D, Zhao D, Sun L, Li X, Wang J (2020) The protective effect of didang tang against AlCl3-induced oxidative stress and apoptosis in PC12 cells through the activation of SIRT1-mediated Akt/Nrf2/HO-1 pathway. Front Pharmacol 11:466. https://doi.org/10.3389/fphar.2020.00466
doi: 10.3389/fphar.2020.00466
pubmed: 32372957
pmcid: 7179660
Ma K, Lu N, Zou F, Meng FZ (2019b) Sirtuins as novel targets in the pathogenesis of airway inflammation in bronchial asthma. Eur J Pharmacol 865:172670. https://doi.org/10.1016/j.ejphar.2019.172670
doi: 10.1016/j.ejphar.2019.172670
pubmed: 31542484
Ma J, Zhang Y, Ji H, Chen L, Chen T, Guo C, Zhang S, Jia J, Niu P (2019a) Overexpression of miR-138–5p suppresses MnCl
doi: 10.1002/tox.22708
pubmed: 30672645
Martins AC Jr, Gubert P, Villas Boas GR, Meirelles Paes M, Santamaría A, Lee E, Tinkov AA, Bowman AB, Aschner M (2020) Manganese-induced neurodegenerative diseases and possible therapeutic approaches. Expert Rev Neurother 20(11):1109–1121. https://doi.org/10.1080/14737175.2020.1807330
doi: 10.1080/14737175.2020.1807330
pubmed: 32799578
Matos L, Gouveia AM, Almeida H (2017) Resveratrol attenuates copper-induced senescence by improving cellular proteostasis. Oxid Med Cell Longev 207:9172085
Mendes KL, Lelis DF, Santos SHS (2017) Nuclear sirtuins and inflammatory signaling pathways. Cytokine Growth Factor Rev. https://doi.org/10.1016/j.cytogfr.2017.11.001
doi: 10.1016/j.cytogfr.2017.11.001
pubmed: 29132743
Min Z, Gao J, Yu Y (2019) The roles of mitochondrial SIRT4 in cellular metabolism. Front Endocrinol (Lausanne) 9:783. https://doi.org/10.3389/fendo.2018.00783
doi: 10.3389/fendo.2018.00783
Mohammed ET, Hashem KS, Abdelazem AZ, Foda FAMA (2020) Prospective protective effect of ellagic acid as a SIRT1 activator in iron oxide nanoparticle-induced renal damage in rats. Biol Trace Elem Res 198(1):177–188. https://doi.org/10.1007/s12011-020-02034-w
doi: 10.1007/s12011-020-02034-w
pubmed: 31933277
Momeny M, Zakidizaji M, Ghasemi R, Dehpour AR, Rahimi-Balaei M, Abdolazimi Y, Ghavamzadeh A, Alimoghaddam K, Ghaffari SH (2010) Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2 BCL-XL and survivin. Med Oncol 27(3):833–842. https://doi.org/10.1007/s12032-009-9294-9
doi: 10.1007/s12032-009-9294-9
pubmed: 19763917
Nam SM, Choi SH, Cho HJ, Seo JS, Choi M, Nahm SS, Chang BJ, Nah SY (2020) Ginseng gintonin attenuates lead-induced rat cerebellar impairments during gestation and lactation. Biomolecules 10(3):385. https://doi.org/10.3390/biom10030385
doi: 10.3390/biom10030385
pmcid: 7175158
Nassir F, Ibdah JA (2016) Sirtuins and nonalcoholic fatty liver disease. World J Gastroenterol 22(46):10084–10092. https://doi.org/10.3748/wjg.v22.i46.10084
doi: 10.3748/wjg.v22.i46.10084
pubmed: 28028356
pmcid: 5155167
Nijhawan P, Behl T (2020) Role of sirtuins in obesity. Obes Med 17:100156
doi: 10.1016/j.obmed.2019.100156
Niska K, Pyszka K, Tukaj C, Wozniak M, Radomski MW, Inkielewicz-Stepniak I (2015) Titanium dioxide nanoparticles enhance production of superoxide anion and alter the antioxidant system in human osteoblast cells. Int J Nanomed 10:1095–1107. https://doi.org/10.2147/IJN.S73557
doi: 10.2147/IJN.S73557
Niyomchan A, Watcharasit P, Visitnonthachai D, Homkajorn B, Thiantanawat A, Satayavivad J (2015) Insulin attenuates arsenic-induced neurite outgrowth impairments by activating the PI3K/Akt/SIRT1 signaling pathway. Toxicol Lett 236(3):138–144. https://doi.org/10.1016/j.toxlet.2015.05.008
doi: 10.1016/j.toxlet.2015.05.008
pubmed: 25982963
Padmaja Divya S, Pratheeshkumar P, Son YO, Vinod Roy R, Andrew Hitron J, Kim D, Dai J, Wang L, Asha P, Huang B, Xu M, Luo J, Zhang Z (2015) Arsenic induces insulin resistance in mouse adipocytes and myotubes via oxidative stress-regulated mitochondrial Sirt3-FOXO3a signaling pathway. Toxicol Sci 146(2):290–300. https://doi.org/10.1093/toxsci/kfv089
doi: 10.1093/toxsci/kfv089
pubmed: 25979314
Pereira TC, Campos MM, Bogo MR (2016) Copper toxicology, oxidative stress and inflammation using zebrafish as experimental model. J Appl Toxicol 36(7):876–885. https://doi.org/10.1002/jat.3303
doi: 10.1002/jat.3303
Pi H, Xu S, Reiter RJ, Guo P, Zhang L, Li Y, Li M, Cao Z, Tian L, Xie J, Zhang R, He M, Lu Y, Liu C, Duan W, Yu Z, Zhou Z (2015) SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy 11(7):1037–1051. https://doi.org/10.1080/15548627.2015.1052208
doi: 10.1080/15548627.2015.1052208
pubmed: 26120888
pmcid: 4590599
Rajabi N, Galleano I, Madsen AS, Olsen CA (2018) Targeting sirtuins: substrate specificity and inhibitor design. Prog Mol Biol Transl Sci 154:25–69. https://doi.org/10.1016/bs.pmbts.2017.11.003
doi: 10.1016/bs.pmbts.2017.11.003
pubmed: 29413177
Ren Z, He H, Zuo Z, Xu Z, Wei Z, Deng J (2019) The role of different SIRT1-mediated signaling pathways in toxic injury. Cell Mol Biol Lett 24:36. https://doi.org/10.1186/s11658-019-0158-9
doi: 10.1186/s11658-019-0158-9
pubmed: 31164908
pmcid: 6543624
Renu K, Madhyastha H, Madhyastha R, Maruyama M, Arunachlam S, Abilash VG (2018) Role of arsenic exposure in adipose tissue dysfunction and its possible implication in diabetes pathophysiology. Toxicol Lett 284:86–95. https://doi.org/10.1016/j.toxlet.2017.11.032
doi: 10.1016/j.toxlet.2017.11.032
pubmed: 29198881
Rezaei M, Keshtzar E, Khodayar MJ, Javadipour M (2019) SirT3 regulates diabetogenic effects caused by arsenic: an implication for mitochondrial complex II modification. Toxicol Lett 301:24–33. https://doi.org/10.1016/j.toxlet.2018.10.025
doi: 10.1016/j.toxlet.2018.10.025
pubmed: 30385301
Ryu JS, Kang HY, Lee JK (2020) Effect of treadmill exercise and trans-cinnamaldehyde against d-galactose- and aluminum chloride-induced cognitive dysfunction in mice. Brain Sci 10(11):793. https://doi.org/10.3390/brainsci10110793
doi: 10.3390/brainsci10110793
pmcid: 7693345
Sanders BD, Jackson B, Marmorstein R (2010) Structural basis for sirtuin function: what we know and what we don’t. Biochimica Biophys Acta 184(8):164–166
Sharma DR, Sunkaria A, Wani WY, Sharma RK, Verma D, Priyanka K, Bal A, Gill KD (2015) Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1α signaling pathway. Neurotoxicology 51:116–137. https://doi.org/10.1016/j.neuro.2015.10.002
doi: 10.1016/j.neuro.2015.10.002
pubmed: 26493151
Shati AA (2019) Resveratrol protects against cadmium chloride-induced hippocampal neurotoxicity by inhibiting ER stress and GAAD 153 and activating sirtuin 1/AMPK/Akt. Environ Toxicol 34(12):1340–1353. https://doi.org/10.1002/tox.22835
doi: 10.1002/tox.22835
pubmed: 31433112
Sheline CT (2012) Involvement of SIRT1 in Zn2+, streptozotocin, non-obese diabetic, and cytokine-mediated toxicities of β-cells. J Diabetes Metab 3(4):1000193. https://doi.org/10.4172/2155-6156.1000193
doi: 10.4172/2155-6156.1000193
pubmed: 23565341
pmcid: 3615451
Shen WT, Huang YJ, Zhang Q, Lin F, Wang X, Ye DY, Huang YP (2020) SCH58261, the antagonist of adenosine A2A receptor, alleviates cadmium-induced preeclampsia via sirtuin-1/hypoxia-inducible factor-1α pathway in rats. Eur Rev Med Pharmacol Sci 24(21):10941–10953. https://doi.org/10.26355/eurrev_202011_23577
doi: 10.26355/eurrev_202011_23577
pubmed: 33215471
Singh CK, Chhabra G, Ndiaye MA, Garcia-Peterson LM, Mack NJ, Ahmad N (2018) The role of sirtuins in antioxidant and redox signaling. Antioxid Redox Signal 28(8):643–661. https://doi.org/10.1089/ars.2017.7290
doi: 10.1089/ars.2017.7290
pubmed: 28891317
pmcid: 5824489
So KY, Park BH, Oh SH (2020) Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity. Cell Biol Toxicol. https://doi.org/10.1007/s10565-020-09528-2
doi: 10.1007/s10565-020-09528-2
pubmed: 32827127
Sun Y, Liu C, Liu Y, Hosokawa T, Saito T, Kurasaki M (2014) Changes in the expression of epigenetic factors during copper-induced apoptosis in PC12 cells. J Environ Sci Health A Tox Hazard Subst Environ Eng 49(9):1023–1028. https://doi.org/10.1080/10934529.2014.894847
doi: 10.1080/10934529.2014.894847
pubmed: 24798901
Sun Q, Kang RR, Chen KG, Liu K, Ma Z, Liu C, Deng Y, Liu W, Xu B (2020) Sirtuin 3 is required for the protective effect of resveratrol on manganese-induced disruption of mitochondrial biogenesis in primary cultured neurons. J Neurochem. https://doi.org/10.1111/jnc.15095
doi: 10.1111/jnc.15095
pubmed: 33336396
pmcid: 7317896
Tam LM, Wang Y (2020) Arsenic exposure and compromised protein quality control. Chem Res Toxicol 33(7):1594–1604. https://doi.org/10.1021/acs.chemrestox.0c00107
doi: 10.1021/acs.chemrestox.0c00107
pubmed: 32410444
Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ (2012) Heavy metal toxicity and the environment. Exp Suppl 101:133–164. https://doi.org/10.1007/978-3-7643-8340-4_6
doi: 10.1007/978-3-7643-8340-4_6
pubmed: 22945569
Tu RQ, Zhang LJ, Feng DM, Li CJ, Fang H, Ma X, Shu TT, Cui LX, Huang H (2016) Effects of maternal lead exposure on expression of 8-OHd G and SIRT1 in brain tissue of mice offspring. J Environ Health 5:5
Tucker EK, Nowak RA (2018) Methylmercury alters proliferation, migration, and antioxidant capacity in human HTR8/SV-neo trophoblast cells. Reprod Toxicol 78:60–68. https://doi.org/10.1016/j.reprotox.2018.03.008
doi: 10.1016/j.reprotox.2018.03.008
pubmed: 29581082
pmcid: 5984162
Wang X, Wang M, Yang L, Bai J, Yan Z, Zhang Y, Liu Z (2014) Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake. Neural Regen Res 9(21):1917–1922. https://doi.org/10.4103/1673-5374.145361
doi: 10.4103/1673-5374.145361
pubmed: 25558243
pmcid: 4281432
Wang Y, He J, Liao M, Hu M, Li W, Ouyang H, Wang X, Ye T, Zhang Y, Ouyang L (2019) An overview of sirtuins as potential therapeutic target: structure, function and modulators. Eur J Med Chem 161:48–77. https://doi.org/10.1016/j.ejmech.2018.10.028
doi: 10.1016/j.ejmech.2018.10.028
pubmed: 30342425
Wang L, Sun M, Cao Y, Ma L, Shen Y, Velikanova AA, Li X, Sun C, Zhao Y (2020) miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload. Arch Biochem Biophys 695:108642. https://doi.org/10.1016/j.abb.2020.108642
doi: 10.1016/j.abb.2020.108642
pubmed: 33098868
Warren EB, Bryan MR, Morcillo P, Hardeman KN, Aschner M, Bowman AB (2020) Manganese-induced mitochondrial dysfunction is not detectable at exposures below the acute cytotoxic threshold in neuronal cell types. Toxicol Sci 176(2):446–459. https://doi.org/10.1093/toxsci/kfaa079
doi: 10.1093/toxsci/kfaa079
pubmed: 32492146
Yan D, Jin C, Cao Y, Wang L, Lu X, Yang J, Wu S, Cai Y (2017) Effects of aluminium on long-term memory in rats and on SIRT1 mediating the transcription of CREB-dependent gene in hippocampus. Basic Clin Pharmacol Toxicol 121(4):342–352. https://doi.org/10.1111/bcpt.12798
doi: 10.1111/bcpt.12798
pubmed: 28429887
Yang D, Tan X, Lv Z, Liu B, Baiyun R, Lu J, Zhang Z (2016) Regulation of Sirt1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity. Sci Rep 6:37157. https://doi.org/10.1038/srep37157
doi: 10.1038/srep37157
pubmed: 27853236
pmcid: 5112569
Yang X, Park SH, Chang HC, Shapiro JS, Vassilopoulos A, Sawicki KT, Chen C, Shang M, Burridge PW, Epting CL, Wilsbacher LD, Jenkitkasemwong S, Knutson M, Gius D, Ardehali H (2017) Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2. J Clin Invest 127(4):1505–1516. https://doi.org/10.1172/JCI88574
doi: 10.1172/JCI88574
pubmed: 28287409
pmcid: 5373873
Yang W, Tian ZK, Yang HX, Feng ZJ, Sun JM, Jiang H, Cheng C, Ming QL, Liu CM (2019) Fisetin improves lead-induced neuroinflammation, apoptosis and synaptic dysfunction in mice associated with the AMPK/SIRT1 and autophagy pathway. Food Chem Toxicol 134:110824. https://doi.org/10.1016/j.fct.2019.11082
doi: 10.1016/j.fct.2019.11082
pubmed: 31539617
Yoshida M, Honda A, Watanabe C, Satoh M, Yasutake A (2014) Neurobehavioral changes in response to alterations in gene expression profiles in the brains of mice exposed to low and high levels of mercury vapor during postnatal development. J Toxicol Sci 39(4):561–570. https://doi.org/10.2131/jts.39.561
doi: 10.2131/jts.39.561
pubmed: 25056781
Yu CW, How CM, Liao VH (2016) Arsenite exposure accelerates aging process regulated by the transcription factor DAF-16/FOXO in Caenorhabditis elegans. Chemosphere 150:632–638. https://doi.org/10.1016/j.chemosphere.2016.01.004
doi: 10.1016/j.chemosphere.2016.01.004
pubmed: 26796881
Zhang L, Tu R, Wang Y, Hu Y, Li X, Cheng X, Yin Y, Li W, Huang H (2017) Early-life exposure to lead induces cognitive impairment in elder mice targeting SIRT1 phosphorylation and oxidative alterations. Front Physiol 8:446. https://doi.org/10.3389/fphys.2017.00446
doi: 10.3389/fphys.2017.00446
pubmed: 28706491
pmcid: 5489681
Zhang Y, Gu W, Duan L, Zhu H, Wang H, Wang J, Sun J, Niu F (2018) Protective effect of dietary fiber from sweet potato (Ipomoea batatas L.) against lead-induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways. J Food Biochem 42(3):e12513
doi: 10.1111/jfbc.12513
Zhang Q, Zhang C, Ge J, Lv MW, Talukder M, Guo K, Li YH, Li JL (2020) Ameliorative effects of resveratrol against cadmium-induced nephrotoxicity via modulating nuclear xenobiotic receptor response and PINK1/Parkin-mediated mitophagy. Food Funct 11(2):1856–1868. https://doi.org/10.1039/c9fo02287b
doi: 10.1039/c9fo02287b
pubmed: 32068207
Zhao X, Jin Y, Yang L, Hou Z, Liu Y, Sun T, Pei J, Li J, Yao C, Wang X, Chen G (2018) Promotion of SIRT1 protein degradation and lower SIRT1 gene expression via reactive oxygen species is involved in Sb-induced apoptosis in BEAS-2b cells. Toxicol Lett 296:73–81. https://doi.org/10.1016/j.toxlet.2018.07.047
doi: 10.1016/j.toxlet.2018.07.047
pubmed: 30055241
Zhao E, Hou J, Ke X, Abbas MN, Kausar S, Zhang L, Cui H (2019a) The roles of sirtuin family proteins in cancer progression. Cancers (Basel) 11(12):1949. https://doi.org/10.3390/cancers11121949
doi: 10.3390/cancers11121949
Zhao X, Liu Y, Zhu G, Liang Y, Liu B, Wu Y, Han M, Sun W, Han Y, Chen G, Jiang J (2019b) SIRT1 downregulation mediated manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis. Sci Total Environ 646:1047–1055. https://doi.org/10.1016/j.scitotenv.2018.07.363
doi: 10.1016/j.scitotenv.2018.07.363
pubmed: 30235590
Zhao Y, Yan J, Li AP, Zhang ZL, Li ZR, Guo KJ, Zhao KC, Ruan Q, Guo L (2019c) Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats. Toxicol Lett 310:31–38. https://doi.org/10.1016/j.toxlet.2019.04.007
doi: 10.1016/j.toxlet.2019.04.007
pubmed: 30974164
Zhao L, Cao J, Hu K, He X, Yun D, Tong T, Han L (2020) Sirtuins and their biological relevance in aging and age-related diseases. Aging Dis 11(4):927–945. https://doi.org/10.14336/AD.2019.0820
doi: 10.14336/AD.2019.0820
pubmed: 32765955
pmcid: 7390530
Zheng X, Li S, Li J, Lv Y, Wang X, Wu P, Yang Q, Tang Y, Liu Y, Zhang Z (2020) Hexavalent chromium induces renal apoptosis and autophagy via disordering the balance of mitochondrial dynamics in rats. Ecotoxicol Environ Saf 204:111061. https://doi.org/10.1016/j.ecoenv.2020.111061
doi: 10.1016/j.ecoenv.2020.111061
pubmed: 32750588
Zhong X, de Cássia da Silveira E Sá R, Zhong C, (2017) Mitochondrial biogenesis in response to chromium (VI) toxicity in human liver cells. Int J Mol Sci 18(9):1877. https://doi.org/10.3390/ijms18091877
doi: 10.3390/ijms18091877
pmcid: 5618526
Zhou Z, Ye TJ, DeCaro E, Buehler B, Stahl Z, Bonavita G, Daniels M, You M (2020) Intestinal SIRT1 deficiency protects mice from ethanol-induced liver injury by mitigating ferroptosis. Am J Pathol 190(1):82–92. https://doi.org/10.1016/j.ajpath.2019.09.012
doi: 10.1016/j.ajpath.2019.09.012
pubmed: 31610175
pmcid: 6943377
Zhou S, Sun L, Qian S, Ma Y, Ma R, Dong Y, Shi Y, Jiang S, Ye H, Shen Z, Zhang S, Shen J, Yu K, Wang S (2021) Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin. Cell Mol Biol Lett 26(1):2. https://doi.org/10.1186/s11658-020-00244-7
doi: 10.1186/s11658-020-00244-7
pubmed: 33435886
pmcid: 7805071
Zullo A, Simone E, Grimaldi M, Musto V, Mancini FP (2018) Sirtuins as mediator of the anti-ageing effects of calorie restriction in skeletal and cardiac muscle. Int J Mol Sci 19(4):928. https://doi.org/10.3390/ijms19040928
doi: 10.3390/ijms19040928
pmcid: 5979282