Immunological role of keratinocytes in leishmaniasis.
healing
immune response
keratinocytes
leishmaniasis
protection
ulcer formation
Journal
Parasite immunology
ISSN: 1365-3024
Titre abrégé: Parasite Immunol
Pays: England
ID NLM: 7910948
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
13
05
2021
received:
28
11
2020
accepted:
15
05
2021
pubmed:
25
5
2021
medline:
26
11
2021
entrez:
24
5
2021
Statut:
ppublish
Résumé
Following inoculation of Leishmania, a protozoan parasite, into the skin of a mammal, the epidermal keratinocytes recognize the parasite and influence the local immune response that can give rise to different outcomes of leishmaniasis. The early keratinocyte-derived cytokines and keratinocytes-T cells interactions shape the anti-leishmanial immune responses that contribute to the resistance or susceptibility to leishmaniasis. The keratinocyte-derived cytokines can directly potentiate the leishmanicidal activity of monocytes and macrophages. As keratinocytes express MHC-II and enhance the expression of costimulatory molecules, these cells act as antigen-presenting cells (APCs) in cutaneous leishmaniasis (CL). Depending on the epidermal microenvironment, the keratinocytes induce various types of effector CD4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12870Informations de copyright
© 2021 John Wiley & Sons Ltd.
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