A prospective, phase II study on the safety and efficacy of negative pressure closure for the stabilization of split-thickness skin graft in large or muscle-exposing defects: The NPSG study.
large defect
muscle-exposing defect
negative pressure closure
prospective study
skin graft
Journal
The Journal of dermatology
ISSN: 1346-8138
Titre abrégé: J Dermatol
Pays: England
ID NLM: 7600545
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
28
04
2021
received:
15
03
2021
accepted:
29
04
2021
pubmed:
25
5
2021
medline:
4
9
2021
entrez:
24
5
2021
Statut:
ppublish
Résumé
Several studies have demonstrated the usefulness of negative pressure closure (NPC) for the stabilization of skin grafts because it provides a uniform pressure to the graft. The results of our previous retrospective study also suggested the superiority of NPC over tie-over methods for the stabilization of split-thickness skin graft (STSG) in large or muscle-exposing defects. However, the usefulness of NPC for graft stabilization is yet to be fully established. This prospective, phase II clinical study was conducted to investigate the safety and efficacy of NPC for the stabilization of STSG in large or muscle-exposing defects. Patients who would require STSG for reconstruction of defects in the trunk and extremities other than hands and feet measuring >10 cm in the longest diameter or with muscle exposure were enrolled. NPC was applied for skin graft stabilization. Seven patients who had received wide excision of malignant tumors and resulted in muscle-exposed skin defects were included. All patients underwent meshed STSG. The mean size of the defect was 94.5 cm
Identifiants
pubmed: 34028872
doi: 10.1111/1346-8138.15970
doi:
Types de publication
Clinical Trial, Phase II
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1350-1356Subventions
Organisme : The Grant for Implementation of Advanced Medicine in University of Tsukuba Hospital
Informations de copyright
© 2021 Japanese Dermatological Association.
Références
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