Stimulus-Responsive Polyelectrolyte Surfaces: Switching Surface Properties from Polycationic/Antimicrobial to Polyzwitterionic/Protein-Repellent.
antimicrobial polymers
polyelectrolytes
polyzwitterions
protein-repellent polymers
stimulus-responsive polymers
Journal
Macromolecular rapid communications
ISSN: 1521-3927
Titre abrégé: Macromol Rapid Commun
Pays: Germany
ID NLM: 9888239
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
20
04
2021
received:
21
01
2021
pubmed:
25
5
2021
medline:
23
9
2021
entrez:
24
5
2021
Statut:
ppublish
Résumé
Surfaces coated with polyzwitterions are most well-known for their ability to resist protein adsorption. In this article, a surface-attached hydrophobically modified poly(carboxybetaine) is presented. When protonated by changes of the pH of the surrounding medium, this protein-repellent polyzwitterion switches to a polycationic state in which it is antimicrobially active and protein-adhesive. The pH range in which these two states exist are recorded by zeta potential measurements. Adsorption studies at different pH values (monitored by surface plasmon resonance spectroscopy) confirm that the adhesion of protein is pH dependent and reversible, that is, protein can be released upon a pH change from pH 3 to pH 7.4. At physiological pH, the poly(carboxyzwitterion) is antimicrobially active, presumably because it becomes protonated by bacterial metabolites during the antimicrobial activity assay. Stability studies confirm that the here presented material is storage-stable, yet hydrolyses after longer incubation in aqueous media.
Identifiants
pubmed: 34028928
doi: 10.1002/marc.202100051
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Polyelectrolytes
0
Polymers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100051Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : 03VP03860
Informations de copyright
© 2021 The Authors. Macromolecular Rapid Communications published by Wiley-VCH GmbH.
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