Spray-dried mucoadhesive microparticles based on S-protected thiolated hydroxypropyl-β-cyclodextrin for budesonide nasal delivery.

2-Hydroxypropyl-beta-cyclodextrin Animals Budesonide Child Drug Compounding Humans Solubility Sulfhydryl Compounds Swine
Allergic Rhinitis Budesonide Hydroxypropyl- β -cyclodextrin Microparticles Mucoadhesion Nasal delivery Spray-drying Thiomers

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
15 Jun 2021
Historique:
received: 17 01 2021
revised: 18 05 2021
accepted: 19 05 2021
pubmed: 25 5 2021
medline: 22 6 2021
entrez: 24 5 2021
Statut: ppublish

Résumé

Budesonide (BUD) is used as first choice therapy for the treatment of allergic rhinitis, a chronic allergic-immune condition with an increased incidence in the pediatric population. The main problem of BUD nasal formulations is related to its poor aqueous solubility (S

Identifiants

DOI: 10.1016/j.ijpharm.2021.120728 PMID: 34029665
pubmed: 34029665
pii: S0378-5173(21)00533-0
doi: 10.1016/j.ijpharm.2021.120728
pii:
doi:

Substances chimiques

Sulfhydryl Compounds 0
2-Hydroxypropyl-beta-cyclodextrin 1I96OHX6EK
Budesonide 51333-22-3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

120728

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Giuseppe Francesco Racaniello (GF)

Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.

Valentino Laquintana (V)

Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.

Simona Summonte (S)

Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy; Thiomatrix Forschungs- und Beratungs GmbH, Research Center Innsbruck, Trientlgasse 65, 6020 Innsbruck, Austria.

Angela Lopedota (A)

Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.

Annalisa Cutrignelli (A)

Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.

Antonio Lopalco (A)

Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.

Massimo Franco (M)

Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.

Andreas Bernkop-Schnürch (A)

Thiomatrix Forschungs- und Beratungs GmbH, Research Center Innsbruck, Trientlgasse 65, 6020 Innsbruck, Austria; Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.

Nunzio Denora (N)

Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy. Electronic address: nunzio.denora@uniba.it.

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Classifications MeSH

questionsmedicales.fr › Glucides › Polyosides › Glucanes › Amidon › Dextrine › Cyclodextrines › Cyclodextrines bêta › 2-Hydroxypropyl-beta-cyclodextrin › Spray-dried mucoadhesive microparticles based...
questionsmedicales.fr › Eucaryotes › Animaux › Spray-dried mucoadhesive microparticles based...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Prégnanes › Prégnènes › Prégnènediones › Budésonide › Spray-dried mucoadhesive microparticles based...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Spray-dried mucoadhesive microparticles based...
questionsmedicales.fr › Techniques d'investigation › Préparation de médicament › Spray-dried mucoadhesive microparticles based...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Spray-dried mucoadhesive microparticles based...
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Spray-dried mucoadhesive microparticles based...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiols › Spray-dried mucoadhesive microparticles based...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Spray-dried mucoadhesive microparticles based...