Hypotheses behind the very rare cases of thrombosis with thrombocytopenia syndrome after SARS-CoV-2 vaccination.
AZD1222
Ad.26.COV2.S
COVID-19
COVID-19 Janssen vaccine
Cerebral venous sinus thrombosis
ChAdOx1 nCov-19
Thrombosis
Vaccines
Journal
Thrombosis research
ISSN: 1879-2472
Titre abrégé: Thromb Res
Pays: United States
ID NLM: 0326377
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
25
04
2021
revised:
07
05
2021
accepted:
08
05
2021
pubmed:
25
5
2021
medline:
24
6
2021
entrez:
24
5
2021
Statut:
ppublish
Résumé
As of 4 April 2021, a total of 169 cases of cerebral venous sinus thrombosis (CVST) and 53 cases of splanchnic vein thrombosis were reported to EudraVigilance among around 34 million people vaccinated in the European Economic Area and United Kingdom with COVID-19 Vaccine AstraZeneca, a chimpanzee adenoviral vector (ChAdOx1) encoding the spike protein antigen of the SARS-CoV-2 virus. The first report of the European Medicines Agency gathering data on 20 million people vaccinated with Vaxzevria® in the UK and the EEA concluded that the number of post-vaccination cases with thromboembolic events as a whole reported to EudraVigilance in relation to the number of people vaccinated was lower than the estimated rate of such events in the general population. However, the EMA's Pharmacovigilance Risk Assessment Committee concluded that unusual thromboses with low blood platelets should be listed as very rare side effects of Vaxzevria®, pointing to a possible link. The same issue was identified with the COVID-19 Vaccine Janssen (Ad26.COV2.S). Currently, there is still a sharp contrast between the clinical or experimental data reported in the literature on COVID-19 and the scarcity of data on the unusual thrombotic events observed after the vaccination with these vaccines. Different hypotheses might support these observations and should trigger further in vitro and ex vivo investigations. Specialized studies were needed to fully understand the potential relationship between vaccination and possible risk factors in order to implement risk minimization strategies.
Identifiants
pubmed: 34029848
pii: S0049-3848(21)00331-5
doi: 10.1016/j.thromres.2021.05.010
pmc: PMC8123522
pii:
doi:
Substances chimiques
COVID-19 Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
163-171Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Références
Thromb Res. 2000 Nov 1;100(3):115-25
pubmed: 11108897
Circ Res. 2020 Sep 17;:
pubmed: 32938299
Virol J. 2009 Feb 17;6:25
pubmed: 19222836
Nat Commun. 2017 May 22;8:14945
pubmed: 28530237
Blood. 2021 Oct 21;138(16):1481-1489
pubmed: 34315173
Purinergic Signal. 2011 Sep;7(3):283-92
pubmed: 21484086
Blood. 2014 May 1;123(18):2759-67
pubmed: 24585776
Blood. 2014 Jun 5;123(23):3651-4
pubmed: 24677540
Thromb Res. 2013 Sep;132(3):352-9
pubmed: 23803389
Blood. 2021 Jul 29;138(4):350-353
pubmed: 34323939
J Thromb Haemost. 2008 Sep;6(9):1598-600
pubmed: 18513213
Br J Haematol. 2003 Dec;123(5):903-5
pubmed: 14632782
Blood. 2014 May 1;123(18):2854-63
pubmed: 24665136
J Thromb Haemost. 2021 May;19(5):1342-1347
pubmed: 33639037
J Infect Dis. 2012 Apr 15;205(8):1321-9
pubmed: 22383677
Int J Mol Sci. 2016 Jan 11;17(1):
pubmed: 26761005
Lancet Haematol. 2020 Aug;7(8):e575-e582
pubmed: 32619411
Blood. 2021 Dec 2;138(22):2256-2268
pubmed: 34587242
Int J Hematol. 2020 Dec;112(6):883-888
pubmed: 32677007
Blood. 2021 Feb 25;137(8):1061-1071
pubmed: 33512415
J Phys Chem B. 2020 Feb 27;124(8):1438-1443
pubmed: 31944769
J Immunol. 2014 May 15;192(10):4674-84
pubmed: 24729609
Blood. 2007 Apr 1;109(7):2832-9
pubmed: 17148587
Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1463-70
pubmed: 17379836
Blood. 2012 Oct 18;120(16):3345-52
pubmed: 22942185
J Infect. 2020 Aug;81(2):e91-e92
pubmed: 32417311
J Clin Invest. 2021 Jun 1;131(11):
pubmed: 33945504
Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2386-93
pubmed: 16873726
Vasc Health Risk Manag. 2019 Oct 22;15:449-461
pubmed: 31695400
Virol J. 2011 Sep 30;8:456
pubmed: 21962080
N Engl J Med. 2021 May 20;384(20):1964-1965
pubmed: 33852795
Blood. 2014 Jun 5;123(23):3536-8
pubmed: 24904101
J Thromb Haemost. 2009 Mar;7(3):499-501
pubmed: 19087219
Lancet. 2021 May 1;397(10285):e11
pubmed: 33864750
Lancet Infect Dis. 2020 Jun;20(6):719-730
pubmed: 32199492
Blood Adv. 2019 Dec 10;3(23):4021-4033
pubmed: 31809536
Front Med (Lausanne). 2019 Apr 12;6:76
pubmed: 31106204
Int J Lab Hematol. 2019 May;41 Suppl 1:15-25
pubmed: 31069988
Sci Transl Med. 2020 Mar 18;12(535):
pubmed: 32188724
J Thromb Haemost. 2019 Feb;17(2):389-399
pubmed: 30582672
J Thromb Haemost. 2013 May;11(5):951-62
pubmed: 23433144
J Thromb Haemost. 2021 Jul;19(7):1831-1832
pubmed: 33904251
Blood. 2015 Jul 16;126(3):378-85
pubmed: 25943787
Blood. 2002 Feb 15;99(4):1230-6
pubmed: 11830470
Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2837-2844
pubmed: 33028093
N Engl J Med. 2021 Jun 10;384(23):2202-2211
pubmed: 33861525
N Engl J Med. 2021 May 20;384(20):1965-1966
pubmed: 33861522
Platelets. 2015;26(6):602-7
pubmed: 25383922
Nat Commun. 2015 Sep 22;6:8277
pubmed: 26391892
Curr Opin Hematol. 2014 Sep;21(5):388-94
pubmed: 25010799
J Thromb Haemost. 2010 Sep;8(9):2025-31
pubmed: 20626620
J Thromb Haemost. 2017 Nov;15(11):2099-2114
pubmed: 28846826
J Hematol Oncol. 2020 Sep 4;13(1):120
pubmed: 32887634
JAMA. 2021 Jun 22;325(24):2448-2456
pubmed: 33929487
Mil Med Res. 2017 Mar 15;4:11
pubmed: 28361006
Blood. 2020 Sep 10;136(11):1317-1329
pubmed: 32573711
Blood. 1986 Feb;67(2):362-5
pubmed: 3002524
Antiviral Res. 2020 May;177:104759
pubmed: 32130973
Thromb Res. 2014 Jun;133(6):1068-73
pubmed: 24360929
Science. 2021 Feb 26;371(6532):
pubmed: 33361116
Nat Commun. 2019 Apr 16;10(1):1780
pubmed: 30992428
Blood. 2015 Nov 26;126(22):2459-65
pubmed: 26582375
MMWR Morb Mortal Wkly Rep. 2021 Apr 30;70(17):651-656
pubmed: 33914723
Platelets. 2021 Feb 17;32(2):284-287
pubmed: 33349108
Circulation. 1999 May 18;99(19):2530-6
pubmed: 10330384
Blood. 2016 Jan 28;127(4):464-72
pubmed: 26518435
N Engl J Med. 2021 Jun 3;384(22):2092-2101
pubmed: 33835769
Blood Adv. 2016 Nov 22;1(1):62-74
pubmed: 29296696
Lancet Infect Dis. 2020 Jun;20(6):707-718
pubmed: 32199491
Blood. 2013 Jul 11;122(2):272-81
pubmed: 23673861
Thromb Haemost. 2021 Jul;121(7):971-975
pubmed: 33296940
J Thromb Haemost. 2021 May;19(5):1294-1298
pubmed: 33550713
N Engl J Med. 2021 Jun 3;384(22):2124-2130
pubmed: 33835768
Anal Chem. 2020 Aug 18;92(16):10930-10934
pubmed: 32678978
J Thromb Haemost. 2011 Oct;9(10):2067-76
pubmed: 21848694
J Thromb Haemost. 2020 Jul;18(7):1738-1742
pubmed: 32302438
Blood. 2011 Jan 27;117(4):1370-8
pubmed: 20959601
Circulation. 2020 Nov 10;142(19):1875-1877
pubmed: 32990022
Nat Med. 2005 Nov;11(11):1167-9
pubmed: 16258538
Am J Med. 2008 Jul;121(7):632-6
pubmed: 18589060
Thromb Haemost. 2021 Nov;121(11):1395-1399
pubmed: 33851389
Nat Rev Neurol. 2017 Sep;13(9):555-565
pubmed: 28820187
Arch Virol. 2015 Nov;160(11):2669-81
pubmed: 26321473
Platelets. 2021 Oct 3;32(7):936-940
pubmed: 33000657
Platelets. 2017 Sep;28(6):614-620
pubmed: 28856946
Blood. 2009 May 14;113(20):4963-9
pubmed: 19144981
Thromb Res. 2020 Jun;190:62
pubmed: 32305740
J Thromb Haemost. 2021 Jul;19(7):1771-1775
pubmed: 33877737