Melanopsin-driven pupil response in summer and winter in unipolar seasonal affective disorder.
Circadian rhythms
Depression
Environment
Iprgc
Melanopsin
Pupillometry
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 08 2021
01 08 2021
Historique:
received:
11
11
2020
revised:
19
02
2021
accepted:
25
04
2021
pubmed:
25
5
2021
medline:
9
7
2021
entrez:
24
5
2021
Statut:
ppublish
Résumé
A retinal subsensitivity to environmental light may trigger Seasonal Affective Disorder (SAD) under low wintertime light conditions. The main aim of this study was to assess the responses of melanopsin-containing retinal ganglion cells in participants (N= 65) diagnosed with unipolar SAD compared to controls with no history of depression. Participants attended a summer visit, a winter visit, or both. Retinal responses to light were measured using the post-illumination pupil response (PIPR) to assess melanopsin-driven responses in the non-visual light input pathway. Linear mixed-effects modeling was used to test a group*season interaction on the Net PIPR (red minus blue light response, percent baseline). We observed a significant group*season interaction such that the PIPR decreased from summer to winter significantly in the SAD group while not in the control group. The SAD group PIPR was significantly lower in winter compared to controls but did not differ between groups in summer. Only 60% of the participants underwent an eye health exam, although all participants reported no history of retinal pathology, and eye exam status was neither associated with outcome nor different between groups. This seasonal variation in melanopsin driven non-visual responses to light may be a risk factor for SAD, and further highlights individual differences in responses to light for direct or indirect effects of light on mood.
Identifiants
pubmed: 34029883
pii: S0165-0327(21)00416-X
doi: 10.1016/j.jad.2021.04.084
pmc: PMC8693789
mid: NIHMS1699583
pii:
doi:
Substances chimiques
Rod Opsins
0
melanopsin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
93-101Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000005
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001857
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH103313
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY009380
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007560
Pays : United States
Organisme : NIMH NIH HHS
ID : R03 MH096119
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY025555
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
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