Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology.
Mitophagy
PINK1
Parkinson disease
XBP1
phosphorylation
transcription
unfolded protein response
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
pubmed:
26
5
2021
medline:
8
4
2022
entrez:
25
5
2021
Statut:
ppublish
Résumé
Parkinson disease (PD)-affected brains show consistent endoplasmic reticulum (ER) stress and mitophagic dysfunctions. The mechanisms underlying these perturbations and how they are directly linked remain a matter of questions. XBP1 is a transcription factor activated upon ER stress after unconventional splicing by the nuclease ERN1/IREα thereby yielding XBP1s, whereas PINK1 is a kinase considered as the sensor of mitochondrial physiology and a master gatekeeper of mitophagy process. We showed that XBP1s transactivates
Identifiants
pubmed: 34030589
doi: 10.1080/15548627.2021.1917129
pmc: PMC8726674
doi:
Substances chimiques
X-Box Binding Protein 1
0
Xbp1 protein, mouse
0
Protein Kinases
EC 2.7.-
PTEN-induced putative kinase
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Endoribonucleases
EC 3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4363-4385Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
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