Management of atypical uremic hemolytic syndrome in pregnant patient.
Manejo de síndrome hemolítico urémico atípico en la paciente gestante.
Embarazo
Haemolytic uremic síndrome
Microangiopatía trombótica
Pregnancy
Síndrome hemolítico urémico
Trombotic microangiopathy
Journal
Revista espanola de anestesiologia y reanimacion
ISSN: 2341-1929
Titre abrégé: Rev Esp Anestesiol Reanim (Engl Ed)
Pays: Spain
ID NLM: 101778594
Informations de publication
Date de publication:
21 May 2021
21 May 2021
Historique:
received:
15
05
2020
revised:
11
12
2020
accepted:
14
12
2020
entrez:
25
5
2021
pubmed:
26
5
2021
medline:
26
5
2021
Statut:
aheadofprint
Résumé
Atypical uremic haemolytic syndrome is a variant of thrombotic micro-andiopathy characterized by non-autoimmune hemolytic anemia, thrombocytopenia and acute renal failure as a result of excessive activation of the complement. Up to 60% of patients have mutations in the genes that encode the complement system. A disensing factor is required for its manifestation, including gestation. It is an entity with a high morbidity, which can decrease drastically if an early diagnosis is made and appropriate treatment is initiated. Administration of ecuilizumab has demonstrated rapid process disruption, reducing the need for extrarenal purification therapies and improving renal function and patient prognosis.
Identifiants
pubmed: 34030878
pii: S0034-9356(21)00057-8
doi: 10.1016/j.redar.2020.12.012
pii:
doi:
Types de publication
Case Reports
Langues
eng
spa
Informations de copyright
Publicado por Elsevier España, S.L.U.