First-Line Afatinib plus Cetuximab for

Adult Afatinib / adverse effects Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols / adverse effects Carcinoma, Non-Small-Cell Lung / drug therapy Cetuximab / adverse effects ErbB Receptors / genetics Female Humans Lung Neoplasms / drug therapy Male Middle Aged Mutation Treatment Outcome

Journal

Clinical cancer research : an official journal of the American Association for Cancer Research

ISSN: 1557-3265

Titre abrégé: Clin Cancer Res

Pays: United States

ID NLM: 9502500

Informations de publication

Date de publication:
01 08 2021

Historique:

received: 26 11 2020

revised: 12 02 2021

accepted: 20 05 2021

pubmed: 26 5 2021

medline: 2 4 2022

entrez: 25 5 2021

Statut: ppublish

Résumé

Double inhibition of epidermal growth factor receptor (EGFR) using a tyrosine kinase inhibitor plus a monoclonal antibody may be a novel treatment strategy for non-small cell lung cancer (NSCLC). We assessed the efficacy and toxicity of afatinib + cetuximab versus afatinib alone in the first-line treatment of advanced In this phase II, randomized, open-label study, patients with stage III/IV Between June 2016 and November 2018, 59 patients were included in group A and 58 in group A + C. The study was ended early after a futility analysis was performed. The percentage of patients without treatment failure at 9 months was similar for both groups (59.3% for group A vs. 64.9% for group A + C), and median TTF was 11.1 (95% CI, 8.5-14.1) and 12.9 (9.2-14.5) months, respectively. Other endpoints, including progression-free survival and overall survival, also showed no improvement with the combination versus afatinib alone. There was a slight numerical increase in grade ≥3 adverse events in group A + C. Allele frequency of the These results suggest that addition of cetuximab to afatinib does not warrant further investigation in treatment-naïve advanced

Identifiants

DOI: 10.1158/1078-0432.CCR-20-4604 PMID: 34031056

pubmed: 34031056

pii: 1078-0432.CCR-20-4604

doi: 10.1158/1078-0432.CCR-20-4604

doi:

Substances chimiques

Afatinib 41UD74L59M

EGFR protein, human EC 2.7.10.1

ErbB Receptors EC 2.7.10.1

Cetuximab PQX0D8J21J

Types de publication

Clinical Trial, Phase II Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

4168-4176

Informations de copyright

Références

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