Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Among Skilled Nursing Facility Residents and Staff Members-Los Angeles County, August-September 2020.

COVID-19 / epidemiology Health Personnel Humans Los Angeles / epidemiology SARS-CoV-2 / isolation & purification Seroepidemiologic Studies Skilled Nursing Facilities
COVID-19 SARS-CoV-2 Seroprevalence Skilled nursing facilities

Journal

The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675

Informations de publication

Date de publication:
01 02 2022
Historique:
received: 05 02 2021
accepted: 20 05 2021
pubmed: 26 5 2021
medline: 10 2 2022
entrez: 25 5 2021
Statut: ppublish

Résumé

The prevalence of current or past coronavirus disease 2019 in skilled nursing facility (SNF) residents is unknown because of asymptomatic infection and constrained testing capacity early in the pandemic. We conducted a seroprevalence survey to determine a more comprehensive prevalence of past coronavirus disease 2019 in Los Angeles County SNF residents and staff members. We recruited participants from 24 facilities; participants were requested to submit a nasopharyngeal swab sample for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) testing and a serum sample for detection of SARS-CoV-2 antibodies. All participants were cross-referenced with our surveillance database to identify persons with prior positive SARS-CoV-2 results. From 18 August to 24 September 2020, we enrolled 3305 participants (1340 residents and 1965 staff members). Among 856 residents providing serum samples, 362 (42%) had current or past SARS-CoV-2 infection. Of the 346 serology-positive residents, 199 (58%) did not have a documented prior positive SARS-CoV-2 PCR result. Among 1806 staff members providing serum, 454 (25%) had current or past SARS-CoV-2 infection. Of the 447 serology-positive staff members, 353 (79%) did not have a documented prior positive SARS-CoV-2 PCR result. Past testing practices and policies missed a substantial number of SARS-CoV-2 infections in SNF residents and staff members.

Sections du résumé

BACKGROUND
The prevalence of current or past coronavirus disease 2019 in skilled nursing facility (SNF) residents is unknown because of asymptomatic infection and constrained testing capacity early in the pandemic. We conducted a seroprevalence survey to determine a more comprehensive prevalence of past coronavirus disease 2019 in Los Angeles County SNF residents and staff members.
METHODS
We recruited participants from 24 facilities; participants were requested to submit a nasopharyngeal swab sample for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) testing and a serum sample for detection of SARS-CoV-2 antibodies. All participants were cross-referenced with our surveillance database to identify persons with prior positive SARS-CoV-2 results.
RESULTS
From 18 August to 24 September 2020, we enrolled 3305 participants (1340 residents and 1965 staff members). Among 856 residents providing serum samples, 362 (42%) had current or past SARS-CoV-2 infection. Of the 346 serology-positive residents, 199 (58%) did not have a documented prior positive SARS-CoV-2 PCR result. Among 1806 staff members providing serum, 454 (25%) had current or past SARS-CoV-2 infection. Of the 447 serology-positive staff members, 353 (79%) did not have a documented prior positive SARS-CoV-2 PCR result.
CONCLUSIONS
Past testing practices and policies missed a substantial number of SARS-CoV-2 infections in SNF residents and staff members.

Identifiants

DOI: 10.1093/infdis/jiab281 PMID: 34031692 PMC: PMC8243593
pubmed: 34031692
pii: 6283551
doi: 10.1093/infdis/jiab281
pmc: PMC8243593
doi:

Types de publication

Journal Article Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

367-373

Subventions

Organisme : US Department of Health and Human Services

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Auteurs

Jason H Malenfant (JH)

David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.
ORCID: 0000-0002-9624-7811

Michelle Eslami (M)

Rockport Healthcare Services, Los Angeles, California, USA.

Bonnie L Dao (BL)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Leo Moore (L)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Nicole Green (N)

Public Health Laboratory, Los Angeles County Department of Public Health, Los Angeles, California, USA.

David Silver (D)

Rockport Healthcare Services, Los Angeles, California, USA.

Kelsey OYong (K)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Ashutosh Ruparelia (A)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Rebecca Fisher (R)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Julia S Wood (JS)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Mohammad Faisal (M)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Faith Washburn (F)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Steve Shvartsblat (S)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Mirna P Jewell (MP)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Tiffany Romo (T)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Chelsea Foo (C)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Angela Salazar (A)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Suzette Aguirre (S)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Sharon Balter (S)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Sandeep Bhaurla (S)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Sandra Buenrrostro (S)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Kim Bui (K)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Karen Young Cho (KY)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Katie Chun (K)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Rachel Civen (R)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Anthony Clarke (A)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Phoebe Danza (P)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Priyanka Fernandes (P)

David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.

Nicole Fountas (N)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Marie Gambon (M)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Candace M Gragnani (CM)

David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.

Amber Griffin (A)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Lidia Guerra (L)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Annette Guerrero (A)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Kay Hooshmand (K)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

M Claire Jarashow (M)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Wendy Knight (W)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Alice A Kuo (AA)

David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.

Thoa Ngo (T)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Denise M Nunez (DM)

David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Aya Obara (A)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Katherine Rawson (K)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Dawn Terashita (D)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Shobita Rajagopalan (S)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Zachary A Rubin (ZA)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

Prabhu Gounder (P)

Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, California, USA.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Seroprevalence of Severe Acute Respiratory...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Personnel de santé › Seroprevalence of Severe Acute Respiratory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Seroprevalence of Severe Acute Respiratory...
questionsmedicales.fr › Régions géographiques › Villes › Los Angeles › Seroprevalence of Severe Acute Respiratory...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Seroprevalence of Severe Acute Respiratory...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études séroépidémiologiques › Seroprevalence of Severe Acute Respiratory...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Établissements de soins de long séjour › Maisons de repos › Établissements de soins qualifiés › Seroprevalence of Severe Acute Respiratory...