Clinical MR imaging in Parkinson's disease: How useful is the swallow tail sign?
Neuroimaging
Parkinson's disease
SWI
susceptibility-weighted imaging
swallow tail sign
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
01
04
2021
received:
15
02
2021
accepted:
11
05
2021
pubmed:
26
5
2021
medline:
12
8
2021
entrez:
25
5
2021
Statut:
ppublish
Résumé
With conventional MRI, no Parkinson's disease (PD)-specific abnormalities can be detected. However, there is a critical need for accompanying neuroimaging markers to guide the diagnosis. With high-resolution susceptibility-weighted MRI (SWI) sequences, the imaging of nigrosome-1 (N1) is possible. The so-called swallow tail sign (STS) has been proposed as a suitable neuroimaging marker for the diagnosis of PD. To investigate whether the absence of the STS can be applied for distinguishing PD patients from healthy controls (HCs). SWI images of 44 PD patients and 50 age- and gender-matched HCs were investigated using a 3T MRI scanner. Two trained neuroradiologists blind-rated the images and evaluated whether the STS was absent (1) on one side or (2) both sides of the participant's midbrain. Our results confirmed good interrater reliability comparable to previously published studies. However, we did not identify any group differences between PD patients and HCs. Measures of diagnostic values revealed overall poor diagnostic performance. Even though previously stated, our study does not confirm the potential use of the STS as a supportive neuroimaging marker for PD in a clinical setting. In conclusion, there is a critical need for improvements in N1-targeted MRI sequences and the development of advanced segmentation algorithms.
Sections du résumé
BACKGROUND
With conventional MRI, no Parkinson's disease (PD)-specific abnormalities can be detected. However, there is a critical need for accompanying neuroimaging markers to guide the diagnosis. With high-resolution susceptibility-weighted MRI (SWI) sequences, the imaging of nigrosome-1 (N1) is possible. The so-called swallow tail sign (STS) has been proposed as a suitable neuroimaging marker for the diagnosis of PD.
OBJECTIVES
To investigate whether the absence of the STS can be applied for distinguishing PD patients from healthy controls (HCs).
METHODS
SWI images of 44 PD patients and 50 age- and gender-matched HCs were investigated using a 3T MRI scanner. Two trained neuroradiologists blind-rated the images and evaluated whether the STS was absent (1) on one side or (2) both sides of the participant's midbrain.
RESULTS
Our results confirmed good interrater reliability comparable to previously published studies. However, we did not identify any group differences between PD patients and HCs. Measures of diagnostic values revealed overall poor diagnostic performance.
CONCLUSIONS
Even though previously stated, our study does not confirm the potential use of the STS as a supportive neuroimaging marker for PD in a clinical setting. In conclusion, there is a critical need for improvements in N1-targeted MRI sequences and the development of advanced segmentation algorithms.
Identifiants
pubmed: 34032020
doi: 10.1002/brb3.2202
pmc: PMC8323030
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e02202Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : BR4328.2-1
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG-GEPRIS 413535489
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK1957
Organisme : Deutsche Parkinsongesellschaft
Organisme : Parkinson's Foundation
Informations de copyright
© 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
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