The RagA and RagB proteins of Porphyromonas gingivalis.
RagAB
periodontal diseasess
porphyromonas
structure function
virulence
Journal
Molecular oral microbiology
ISSN: 2041-1014
Titre abrégé: Mol Oral Microbiol
Pays: Denmark
ID NLM: 101524770
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
05
05
2021
received:
09
02
2021
accepted:
07
05
2021
pubmed:
26
5
2021
medline:
21
8
2021
entrez:
25
5
2021
Statut:
ppublish
Résumé
RagA and RagB proteins are major components of the outer membrane of the oral pathogen Porphyromonas gingivalis and, while recently suggested to represent a novel peptide uptake system, their full function is still under investigation. Herein, we (a) discuss the evidence that the rag locus contributes to P. gingivalis virulence; (b) provide insight to Rag protein potential biological function in macromolecular transport and other aspects of bacterial physiology; (c) address the host response to Rag proteins which are immunodominant and immunomodulatory; and (d) review the potential of Rag-focused therapeutic strategies for the control of periodontal diseases.
Identifiants
pubmed: 34032024
doi: 10.1111/omi.12345
pmc: PMC8349833
mid: NIHMS1707861
doi:
Substances chimiques
Bacterial Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Pagination
225-232Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE026963
Pays : United States
Organisme : NIDCR NIH HHS
ID : R21 DE028506
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM125504
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE022597
Pays : United States
Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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