Incidence of Mild Cognitive Impairment, Conversion to Probable Dementia, and Mortality.
cognition
cognitive dysfunction
dementia
multistate modeling
Journal
American journal of Alzheimer's disease and other dementias
ISSN: 1938-2731
Titre abrégé: Am J Alzheimers Dis Other Demen
Pays: United States
ID NLM: 101082834
Informations de publication
Date de publication:
Historique:
entrez:
25
5
2021
pubmed:
26
5
2021
medline:
29
6
2021
Statut:
ppublish
Résumé
Few studies have jointly estimated incidence of MCI, conversion to probable dementia, and mortality in a nationally representatie sample. We used data from six waves of the National Health and Aging Trends Study (2011-2016). Multivariable-adjusted multi-state survival models (MSMs) were used to model incidence upon accounting for misclassification. A total of 6,078 eligible NHATS participants were included (average age: 77.49 ± 7.79 years; 58.42% females; 68.99% non-Hispanic white). The incidence of MCI was estimated to be 41.0 [35.5, 47.3]/1,000 person-years (PY). Participants converted to probable dementia at a high rate of 241.3 [189.6, 307.0]/1,000 PY, though a small number also reverted from MCI to cognitively normal. Education was associated with lower incidence of MCI and conversion to probable dementia, but increased mortality in those with MCI. There were also substantial racial and ethnic disparities in the incidence of MCI and dementia. Our results underscore the relatively common incidence of and conversions between MCI and dementia in community-dwelling older Americans and uncover the beneficial impact of education to withstand cognitive impairment before death.
Sections du résumé
BACKGROUND
Few studies have jointly estimated incidence of MCI, conversion to probable dementia, and mortality in a nationally representatie sample.
METHODS
We used data from six waves of the National Health and Aging Trends Study (2011-2016). Multivariable-adjusted multi-state survival models (MSMs) were used to model incidence upon accounting for misclassification.
RESULTS
A total of 6,078 eligible NHATS participants were included (average age: 77.49 ± 7.79 years; 58.42% females; 68.99% non-Hispanic white). The incidence of MCI was estimated to be 41.0 [35.5, 47.3]/1,000 person-years (PY). Participants converted to probable dementia at a high rate of 241.3 [189.6, 307.0]/1,000 PY, though a small number also reverted from MCI to cognitively normal. Education was associated with lower incidence of MCI and conversion to probable dementia, but increased mortality in those with MCI. There were also substantial racial and ethnic disparities in the incidence of MCI and dementia.
CONCLUSIONS
Our results underscore the relatively common incidence of and conversions between MCI and dementia in community-dwelling older Americans and uncover the beneficial impact of education to withstand cognitive impairment before death.
Identifiants
pubmed: 34032119
doi: 10.1177/15333175211012235
pmc: PMC8715729
mid: NIHMS1765991
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
15333175211012235Subventions
Organisme : NIA NIH HHS
ID : R01 AG067621
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058595
Pays : United States
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