The effects of acupuncture for patients with psoriasis: Study protocol for a randomized controlled trial.
Acupuncture Therapy
/ methods
Adolescent
Adult
Aged
Anxiety
/ diagnosis
Depression
/ diagnosis
Female
Humans
Male
Middle Aged
Patient Health Questionnaire
/ statistics & numerical data
Psoriasis
/ complications
Quality of Life
Randomized Controlled Trials as Topic
Severity of Illness Index
Treatment Outcome
Young Adult
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
28 May 2021
28 May 2021
Historique:
received:
28
04
2021
accepted:
04
05
2021
entrez:
25
5
2021
pubmed:
26
5
2021
medline:
4
6
2021
Statut:
ppublish
Résumé
Psoriasis is a common chronic relapsing inflammatory skin disease, which may have considerable detrimental effects on the quality of life. Considering high costs and side effects associated with the use of conventional medications, acupuncture, as one of complementary and alternative nonpharmacological therapies, is commonly used in the management of psoriasis for reducing itching, repairing the skin lesions, etc. However, the effects of acupuncture in the management of psoriasis are still inconsistent, especially in psychosocial abnormality due to psoriasis. Therefore, we designed a randomized controlled trials (RCT) involving a placebo control to ensure participants' blinding to investigate the effects of acupuncture for psoriasis in improving typical clinical symptoms and psychosocial abnormality. A singlecenter RCT was designed. 220 participants who meet the eligibility criteria will be randomly allocated into manual acupuncture group or sham acupuncture group in a 1:1 ratio. Participants will respectively receive 15 minutes manual acupuncture or sham acupuncture per session, 3 sessions per week, totally 12 weeks. Psoriasis Area and Severity Index scores, body surface area (BSA), Medical Outcomes Study 36-Item Short-Form Health Survey, Montgomery-Asberg Depression Rating Scale, and Depression, Anxiety, and Stress Scale-21 will be evaluated by blinded operators at baseline and 12 weeks. All analyses will be based on an intention-to-treat principle. The results will be published in an international peer-reviewed journal. The results of this study are expected to clarify the effects of acupuncture on improving typical clinical symptoms and psychosocial abnormality of patients with psoriasis. It will contribute to clinical practice of acupuncture in the management of psoriasis. Chinese Clinical Trail Registry: ChiCTR2100045481. Registration date: April 17, 2021.
Identifiants
pubmed: 34032729
doi: 10.1097/MD.0000000000026042
pii: 00005792-202105280-00039
pmc: PMC8154484
doi:
Types de publication
Clinical Trial Protocol
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e26042Subventions
Organisme : Shanghai Natural Science Foundation of China
ID : 19ZR1407600
Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interests to disclose.
Références
J Med Internet Res. 2010 Dec 19;12(5):e49
pubmed: 21169165
J Dermatolog Treat. 2017 May;28(3):221-228
pubmed: 27631690
J Clin Med. 2019 Jul 31;8(8):
pubmed: 31370200
JAMA Dermatol. 2018 Nov 1;154(11):1330-1337
pubmed: 30193251
Scand J Psychol. 2014 Feb;55(1):83-9
pubmed: 24256317
Forsch Komplementmed. 2015;22(2):102-9
pubmed: 26021960
Med Care. 1992 Jun;30(6):473-83
pubmed: 1593914
J Invest Dermatol. 2015 Apr;135(4):984-991
pubmed: 25521458
Dermatol Ther (Heidelb). 2020 Apr;10(2):285-296
pubmed: 32146709
J Invest Dermatol. 2013 Feb;133(2):377-85
pubmed: 23014338
Microb Pathog. 2018 Apr;117:27-31
pubmed: 29428424
Radiol Case Rep. 2018 Mar 02;13(2):460-463
pubmed: 29682135
Arch Dermatol Res. 2018 Jul;310(5):443-451
pubmed: 29687328
Br J Psychiatry. 1979 Apr;134:382-9
pubmed: 444788
Complement Ther Clin Pract. 2018 May;31:31-37
pubmed: 29705474
J Eur Acad Dermatol Venereol. 2019 Mar;33(3):568-576
pubmed: 30325534
Am J Clin Dermatol. 2014 Dec;15(6):543-9
pubmed: 25217234
J Eur Acad Dermatol Venereol. 2017 Sep;31(9):1491-1496
pubmed: 28585707
J Am Acad Dermatol. 2008 May;58(5):826-50
pubmed: 18423260