Extended retrospective detection of regenerated sarin (GB) in rabbit blood and the IMPA metabolite in urine: a pharmacokinetics study.
Blood
GB
IMPA
Metabolite
Nerve agents
Pharmacokinetics
Urine
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
17
03
2021
accepted:
17
05
2021
pubmed:
26
5
2021
medline:
5
4
2022
entrez:
25
5
2021
Statut:
ppublish
Résumé
Long-term retrospective monitoring of exposure to organophosphorus nerve agents is challenging. We recently developed two highly sensitive analytical methods for regenerated sarin (GB) nerve agent in blood and its primary metabolite, isopropyl-methylphosphonic acid (IMPA), in urine. These methods were implemented in a toxicokinetics study carried out with sarin injected (i.v.) to rabbits at doses corresponding to 0.1, 0.5 or 0.9 LD
Identifiants
pubmed: 34032868
doi: 10.1007/s00204-021-03085-1
pii: 10.1007/s00204-021-03085-1
doi:
Substances chimiques
Chemical Warfare Agents
0
Organophosphorus Compounds
0
isopropyl methylphosphonic acid
1832-54-8
Sarin
B4XG72QGFM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2403-2412Références
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