The cytoskeleton in phagocytosis and macropinocytosis.

Animals Cytoskeleton / metabolism Dendritic Cells / cytology Humans Macrophages / cytology Neutrophils / cytology Phagocytosis Pinocytosis Pseudopodia / metabolism

Journal

Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782

Informations de publication

Date de publication:
24 05 2021
Historique:
entrez: 25 5 2021
pubmed: 26 5 2021
medline: 8 2 2022
Statut: ppublish

Résumé

Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells, perform essential antimicrobial and homeostatic functions. These functions rely on the dynamic surveillance of the environment supported by the formation of elaborate membrane protrusions. Such protrusions - pseudopodia, lamellipodia and filopodia - facilitate the sampling of the surrounding fluid by macropinocytosis, as well as the engulfment of particulates by phagocytosis. Both processes entail extreme plasma membrane deformations that require the coordinated rearrangement of cytoskeletal polymers, which exert protrusive force and drive membrane coalescence and scission. The resulting vacuolar compartments undergo pronounced remodeling and ultimate resolution by mechanisms that also involve the cytoskeleton. Here, we describe the regulation and functions of cytoskeletal assembly and remodeling during macropinocytosis and phagocytosis.

Identifiants

DOI: 10.1016/j.cub.2021.01.036 PMID: 34033794
pubmed: 34033794
pii: S0960-9822(21)00069-5
doi: 10.1016/j.cub.2021.01.036
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

R619-R632

Subventions

Organisme : CIHR
ID : PJT-169180
Pays : Canada
Organisme : CIHR
ID : FDN-143202
Pays : Canada

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Sivakami Mylvaganam (S)

Program in Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.

Spencer A Freeman (SA)

Program in Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: spencer.freeman@sickkids.ca.

Sergio Grinstein (S)

Program in Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: sergio.grinstein@sickkids.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The cytoskeleton in phagocytosis and macropinocytosis.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › The cytoskeleton in phagocytosis and macropinocytosis.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › The cytoskeleton in phagocytosis and macropinocytosis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The cytoskeleton in phagocytosis and macropinocytosis.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › The cytoskeleton in phagocytosis and macropinocytosis.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › The cytoskeleton in phagocytosis and macropinocytosis.
questionsmedicales.fr › Phénomènes du système immunitaire › Phagocytose › The cytoskeleton in phagocytosis and macropinocytosis.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Endocytose › Pinocytose › The cytoskeleton in phagocytosis and macropinocytosis.
questionsmedicales.fr › Cellules › Structures cellulaires › Prolongements cytoplasmiques › Pseudopodes › The cytoskeleton in phagocytosis and macropinocytosis.