Altered maturation and atypical cortical processing of spoken sentences in autism spectrum disorder.
Auditory
Autism
Event-related fields
Language
Magnetoencephalography
Speech
Journal
Progress in neurobiology
ISSN: 1873-5118
Titre abrégé: Prog Neurobiol
Pays: England
ID NLM: 0370121
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
15
01
2021
revised:
14
04
2021
accepted:
19
05
2021
pubmed:
26
5
2021
medline:
15
2
2022
entrez:
25
5
2021
Statut:
ppublish
Résumé
Autism spectrum disorder (ASD) is associated with widespread receptive language impairments, yet the neural mechanisms underlying these deficits are poorly understood. Neuroimaging has shown that processing of socially-relevant sounds, including speech and non-speech, is atypical in ASD. However, it is unclear how the presence of lexical-semantic meaning affects speech processing in ASD. Here, we recorded magnetoencephalography data from individuals with ASD (N = 22, ages 7-17, 4 females) and typically developing (TD) peers (N = 30, ages 7-17, 5 females) during unattended listening to meaningful auditory speech sentences and meaningless jabberwocky sentences. After adjusting for age, ASD individuals showed stronger responses to meaningless jabberwocky sentences than to meaningful speech sentences in the same left temporal and parietal language regions where TD individuals exhibited stronger responses to meaningful speech. Maturational trajectories of meaningful speech responses were atypical in temporal, but not parietal, regions in ASD. Temporal responses were associated with ASD severity, while parietal responses were associated with aberrant involuntary attentional shifting in ASD. Our findings suggest a receptive speech processing dysfunction in ASD, wherein unattended meaningful speech elicits abnormal engagement of the language system, while unattended meaningless speech, filtered out in TD individuals, engages the language system through involuntary attention capture.
Identifiants
pubmed: 34033856
pii: S0301-0082(21)00091-5
doi: 10.1016/j.pneurobio.2021.102077
pmc: PMC8500341
mid: NIHMS1709682
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102077Subventions
Organisme : NIMH NIH HHS
ID : R01 MH117998
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104585
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB030006
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH116517
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC015989
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD073254
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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