Genetic regressive trajectories in colorectal cancer: A new hallmark of oligo-metastatic disease?
Colorectal cancer
Genetics
Mutations
NGS
Oligo-metastases
Journal
Translational oncology
ISSN: 1936-5233
Titre abrégé: Transl Oncol
Pays: United States
ID NLM: 101472619
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
14
04
2021
revised:
17
05
2021
accepted:
19
05
2021
pubmed:
26
5
2021
medline:
26
5
2021
entrez:
25
5
2021
Statut:
ppublish
Résumé
Colorectal cancer (CRC) originates as consequence of multiple genetic alterations. Some of the involved genes have been extensively studied (APC, TP53, KRAS, SMAD4, PIK3CA, MMR genes) in highly heterogeneous and poly-metastatic cohorts. However, about 10% of metastatic CRC patients presents with an indolent oligo-metastatic disease differently from other patients with poly-metastatic and aggressive clinical course. Which are the genetic dynamics underlying the differences between oligo- and poly-metastatic CRC? The understanding of the genetic trajectories (primary→metastatic) of CRC, in patients selected to represent homogenous clinical models, is crucial to make genotype/phenotype correlations and to identify the molecular events pushing the disease towards an increasing malignant phenotype. This information is crucial to plan innovative therapeutic strategies aimed to reverse or inhibit these phenomena. In the present study, we review the genetic evolution of CRC with the intent to give a developmental perspective on the border line between oligo- and poly-metastatic diseases.
Identifiants
pubmed: 34034007
pii: S1936-5233(21)00123-6
doi: 10.1016/j.tranon.2021.101131
pmc: PMC8144733
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
101131Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
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