α-[Amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile; Configurational equilibria in solution.
E/Z configuration
Formulation
MEK inhibitor
SL 327
Solubility
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
04
02
2021
revised:
21
04
2021
accepted:
27
04
2021
pubmed:
26
5
2021
medline:
3
11
2021
entrez:
25
5
2021
Statut:
ppublish
Résumé
Inconsistent results have been reported for the effects of the mitogen-activating extracellular kinase (MEK) inhibitor α-[amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile (SL 327) on ethanol-induced conditioned place preference (EtOH-CPP). Since such inconsistencies may be due to the configurational composition of administered SL 327, the interconvertibility of the geometric isomers of this class of compounds has been investigated. This study provides conditions for determination of configurational composition of this class of compounds by HPLC and by
Identifiants
pubmed: 34034134
pii: S0045-2068(21)00332-1
doi: 10.1016/j.bioorg.2021.104955
pmc: PMC8217309
mid: NIHMS1702193
pii:
doi:
Substances chimiques
SL 327
0
Solutions
0
Aminoacetonitrile
3739OQ10IJ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
104955Subventions
Organisme : NIMH NIH HHS
ID : HHSN271201000007C
Pays : United States
Organisme : NIDA NIH HHS
ID : HHSN271201300007C
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Références
Eur J Neurosci. 2001 Jul;14(2):342-52
pubmed: 11553284
Behav Neurosci. 2007 Oct;121(5):1119-24
pubmed: 17907844
Eur J Pharmacol. 1991 Aug 14;207(4):351-3
pubmed: 1664338
Learn Mem. 1999 Sep-Oct;6(5):478-90
pubmed: 10541468
Brain Behav Immun. 2011 Jun;25 Suppl 1:S146-54
pubmed: 21377524
Arch Dermatol Res. 2010 Oct;302(8):635-8
pubmed: 20582424
Behav Brain Res. 2011 Mar 1;217(2):399-407
pubmed: 21074569
Alcohol Clin Exp Res. 2015 Mar;39(3):463-75
pubmed: 25703719
J Psychopharmacol. 2017 Jan;31(1):105-114
pubmed: 28072036
J Biol Chem. 2000 Nov 24;275(47):37086-92
pubmed: 10969080
Neuropsychopharmacology. 2011 Feb;36(3):551-8
pubmed: 20980993
J Neurochem. 1991 May;56(5):1789-96
pubmed: 1849553
J Neurosci. 2000 Dec 1;20(23):8701-9
pubmed: 11102476
Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55
pubmed: 19171970
Pharmacol Biochem Behav. 2007 Nov;88(1):39-46
pubmed: 17764731
Br J Pharmacol. 2003 Nov;140(5):831-8
pubmed: 14517176