68Ga-DOTATATE PET/CT Distinguishes Neuroendocrine Tumor Mesenteric Lymph Node Metastasis From an Extensive IgG4-Positive Fibrosis Surrounding It.
Journal
Clinical nuclear medicine
ISSN: 1536-0229
Titre abrégé: Clin Nucl Med
Pays: United States
ID NLM: 7611109
Informations de publication
Date de publication:
01 Oct 2021
01 Oct 2021
Historique:
pubmed:
26
5
2021
medline:
16
10
2021
entrez:
25
5
2021
Statut:
ppublish
Résumé
A 56-year-old woman presented with right iliac fossa pain. Abdominal CT showed a mesenteric mass in the right iliac fossa, adjacent to the vena cava inferior and right ureter. Biopsy of the mass revealed a well-differentiated neuroendocrine tumor. 68Ga-DOTATATE PET/CT showed strong somatostatin receptor expression only within in a small, central area of this mesenteric mass, with faint 68Ga-DOTATATE uptake in the majority of this mesenteric mass. Pathology revealed an IgG4-positive storiform fibrosis surrounding a mesenteric adenopathy. 68Ga-DOTATATE PET/CT discriminates between neuroendocrine tumor lymph node metastases and fibrosis, hereby avoiding potential sampling error of tumor biopsies and guiding surgical approach.
Identifiants
pubmed: 34034320
doi: 10.1097/RLU.0000000000003722
pii: 00003072-202110000-00033
doi:
Substances chimiques
Immunoglobulin G
0
Organometallic Compounds
0
gallium Ga 68 dotatate
9L17Y0H71P
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e510-e512Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest and sources of funding: none declared.
Références
Dasari A, Shen C, Halperin D, et al. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol . 2017;3:1335–1342.
Blažević A, Hofland J, Hofland LJ, et al. Small intestinal neuroendocrine tumours and fibrosis: an entangled conundrum. Endocr Relat Cancer . 2018;25:R115–R130.
Laskaratos FM, Rombouts K, Caplin M, et al. Neuroendocrine tumors and fibrosis: an unsolved mystery? Cancer . 2017;123:4770–4790.
Rodríguez Laval V, Pavel M, Steffen IG, et al. Mesenteric fibrosis in midgut neuroendocrine tumors: functionality and radiological features. Neuroendocrinology . 2018;106:139–147.
Laskaratos FM, Walker M, Wilkins D, et al. Evaluation of clinical prognostic factors and further delineation of the effect of mesenteric fibrosis on survival in advanced midgut neuroendocrine tumours. Neuroendocrinology . 2018;107:292–304.
Druce MR, Bharwani N, Akker SA, et al. Intra-abdominal fibrosis in a recent cohort of patients with neuroendocrine (‘carcinoid’) tumours of the small bowel. QJM . 2010;103:177–185.
Roberts J, Gonzalez RS, Revetta F, et al. Mesenteric tumour deposits arising from small-intestine neuroendocrine tumours are frequently associated with fibrosis and IgG4-expressing plasma cells. Histopathology . 2018;73:795–800.
Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med . 2012;366:539–551.
Daskalakis K, Karakatsanis A, Stålberg P, et al. Clinical signs of fibrosis in small intestinal neuroendocrine tumours. Br J Surg . 2017;104:69–75.
Blažević A, Zandee WT, Franssen GJH, et al. Mesenteric fibrosis and palliative surgery in small intestinal neuroendocrine tumours. Endocr Relat Cancer . 2018;25:245–254.