Diffuse Large B-cell Lymphoma: Unexpected Uptake Observed on Cardiac 123I-MIBG Scintigraphy.
Journal
Clinical nuclear medicine
ISSN: 1536-0229
Titre abrégé: Clin Nucl Med
Pays: United States
ID NLM: 7611109
Informations de publication
Date de publication:
01 Oct 2021
01 Oct 2021
Historique:
pubmed:
26
5
2021
medline:
16
10
2021
entrez:
25
5
2021
Statut:
ppublish
Résumé
A 77-year-old man with parkinsonism was referred to the department of neurology for further examination. Cardiac 123I-MIBG scintigraphy unexpectedly showed strong uptake in the left shoulder, suggestive of MIBG-avid tumors including paraganglioma. MRI revealed multiple nodules suggestive of lymphoma. A biopsy was performed, which led to the pathological diagnosis of diffuse large B-cell lymphoma. Cardiac MIBG scintigraphy sometimes shows unexpected findings outside the mediastinum. In addition, lymphoma should also be added to the list of differential diagnoses for MIBG-positive tumors.
Identifiants
pubmed: 34034331
doi: 10.1097/RLU.0000000000003737
pii: 00003072-202110000-00016
doi:
Substances chimiques
Iodine Radioisotopes
0
Radiopharmaceuticals
0
3-Iodobenzylguanidine
35MRW7B4AD
Iodine-123
8YWR746RPQ
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
850-852Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest and sources of funding: The present study was financially supported by JSPS KAKENHI (grant number 19K17164). The authors have no potential conflicts of interest to disclose.
Références
Marini C, Bandettini di Poggio M, Pomposelli E, et al. Whole body and cardiac metaiodobenzylguanidine kinetics in Parkinson disease and multiple system atrophy: implications for the diagnostic role of imaging. Clin Nucl Med . 2010;35:311–316.
Sharp SE, Trout AT, Weiss BD, et al. MIBG in neuroblastoma diagnostic imaging and therapy. Radiographics . 2016;36:258–278.
Rufini V, Treglia G, Perotti G, et al. The evolution in the use of MIBG scintigraphy in pheochromocytomas and paragangliomas. Hormones (Athens) . 2013;12:58–68.
Wakabayashi H, Konishi T, Yoneyama H, et al. Utility of 123 I-MIBG standardized uptake value in patients with refractory pheochromocytoma and paraganglioma. Asia Ocean J Nucl Med Biol . 2019;7:115–120.
Rainis T, Ben-Haim S, Dickstein G. False positive metaiodobenzylguanidine scan in a patient with a huge adrenocortical carcinoma. J Clin Endocrinol Metab . 2000;85:5–7.
Inoue Y, Akahane M, Kitazawa T, et al. False positive uptake of metaiodobenzylguanidine in hepatocellular carcinoma. Br J Radiol . 2002;75:548–551.
Bhanthumkomol P, Hijioka S, Mizuno N, et al. Uptake of 123 I-metaiodobenzylguanidine by gastrointestinal stromal tumor. Clin J Gastroenterol . 2017;10:364–370.
Sone H, Okuda Y, Nakamura Y, et al. Radioiodinated metaiodobenzylguanidine scintigraphy for pheochromocytoma. A false-positive case of adrenocortical adenoma and literature review. Horm Res . 1996;46:138–142.
Kume H, Nishimura S, Teramoto S, et al. An [123 I]MIBG-positive malignant lymphoma involving the adrenal gland with hypercatecholaminaemia. Clin Radiol . 2008;63:475–477.
Stewart RE, Grossman DM, Shulkin BL, et al. Iodine-131 metaiodobenzylguanidine uptake in infantile myofibromatosis. Clin Nucl Med . 1989;14:344–346.
Leung A, Shapiro B, Hattner R, et al. Specificity of radioiodinated MIBG for neural crest tumors in childhood. J Nucl Med . 1997;38:1352–1357.