Factors associated with negative pleural adenosine deaminase results in the diagnosis of childhood pleural tuberculosis.
Adenosine Deaminase
/ analysis
Adolescent
Blood Urea Nitrogen
Case-Control Studies
Chest Pain
Child
Female
Humans
L-Lactate Dehydrogenase
/ analysis
Logistic Models
Male
Multivariate Analysis
Mycobacterium tuberculosis
/ isolation & purification
Pleural Effusion
/ microbiology
Retrospective Studies
Risk Factors
Sputum
/ microbiology
Tuberculosis, Pleural
/ diagnosis
Adenosine deaminase
Childhood pleural tuberculosis
Diagnosis
Pleural effusion
Risk factor
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
25 May 2021
25 May 2021
Historique:
received:
07
02
2021
accepted:
18
05
2021
entrez:
26
5
2021
pubmed:
27
5
2021
medline:
2
6
2021
Statut:
epublish
Résumé
Until now, the influential factors associated with pleural adenosine deaminase (ADA) activity among children remain unclear. This retrospective study was therefore conducted aiming to investigate the factors associated with negative pleural ADA results in the diagnosis of childhood pleural tuberculosis (TB). Between January 2006 and December 2019, children patients with definite or possible pleural TB were recruited for potential analysis. Then, patients were stratified into two categories: negative pleural ADA results group (experimental group, ≤40 U/L) and positive pleural ADA results group (control group, > 40 U/L). Univariate and multivariate logistic regression analyses were performed to estimate risk factors for negative pleural ADA results. A total of 84 patients with pleural TB were recruited and subsequently classified as experimental (n = 17) and control groups (n = 67). Multivariate analysis (Hosmer-Lemeshow goodness-of-fit test: χ Our findings demonstrated that chest pain, pleural total protein, pleural LDH, and blood urea nitrogen were associated with a negative pleural ADA result for the diagnosis of pleural TB among children. When interpreting pleural ADA levels in children with these characteristics, a careful clinical assessment is required for the pleural TB diagnosis.
Sections du résumé
BACKGROUND
BACKGROUND
Until now, the influential factors associated with pleural adenosine deaminase (ADA) activity among children remain unclear. This retrospective study was therefore conducted aiming to investigate the factors associated with negative pleural ADA results in the diagnosis of childhood pleural tuberculosis (TB).
METHODS
METHODS
Between January 2006 and December 2019, children patients with definite or possible pleural TB were recruited for potential analysis. Then, patients were stratified into two categories: negative pleural ADA results group (experimental group, ≤40 U/L) and positive pleural ADA results group (control group, > 40 U/L). Univariate and multivariate logistic regression analyses were performed to estimate risk factors for negative pleural ADA results.
RESULTS
RESULTS
A total of 84 patients with pleural TB were recruited and subsequently classified as experimental (n = 17) and control groups (n = 67). Multivariate analysis (Hosmer-Lemeshow goodness-of-fit test: χ
CONCLUSION
CONCLUSIONS
Our findings demonstrated that chest pain, pleural total protein, pleural LDH, and blood urea nitrogen were associated with a negative pleural ADA result for the diagnosis of pleural TB among children. When interpreting pleural ADA levels in children with these characteristics, a careful clinical assessment is required for the pleural TB diagnosis.
Identifiants
pubmed: 34034670
doi: 10.1186/s12879-021-06209-1
pii: 10.1186/s12879-021-06209-1
pmc: PMC8152150
doi:
Substances chimiques
L-Lactate Dehydrogenase
EC 1.1.1.27
Adenosine Deaminase
EC 3.5.4.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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