Frequency of Irritable Bowel Syndrome in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern.
Adolescent
Adult
Aged
Brugada Syndrome
/ chemically induced
Female
Gastrointestinal Diseases
/ epidemiology
Humans
Irritable Bowel Syndrome
/ epidemiology
Male
Middle Aged
Migraine Disorders
/ epidemiology
NAV1.5 Voltage-Gated Sodium Channel
/ genetics
Voltage-Gated Sodium Channel beta-1 Subunit
/ genetics
Young Adult
Journal
The American journal of cardiology
ISSN: 1879-1913
Titre abrégé: Am J Cardiol
Pays: United States
ID NLM: 0207277
Informations de publication
Date de publication:
15 07 2021
15 07 2021
Historique:
received:
22
02
2021
revised:
02
04
2021
accepted:
05
04
2021
pubmed:
27
5
2021
medline:
14
9
2021
entrez:
26
5
2021
Statut:
ppublish
Résumé
Irritable bowel syndrome (IBS) is one of the most widely recognized functional bowel disorders (FBDs) with a genetic component. SCN5A gene and SCN1B loci have been identified in population-based IBS cohorts and proposed to have a mechanistic role in the pathophysiology of IBS. These same genes have been associated with Brugada syndrome (BrS). The present study examines the hypothesis that these two inherited syndromes are linked. Prevalence of FBDs over a 12 months period were compared between probands with BrS/drug-induced type 1 Brugada pattern (DI-Type 1 BrP) (n = 148) and a control group (n = 124) matched for age, female sex, presence of arrhythmia and co-morbid conditions. SCN5A/SCN1B genes were screened in 88 patients. Prevalence of IBS was 25% in patients with BrS/DI-Type 1 BrP and 8.1% in the control group (p = 2.34 × 10
Identifiants
pubmed: 34034907
pii: S0002-9149(21)00363-5
doi: 10.1016/j.amjcard.2021.04.010
pmc: PMC9148266
mid: NIHMS1697112
pii:
doi:
Substances chimiques
NAV1.5 Voltage-Gated Sodium Channel
0
SCN1B protein, human
0
SCN5A protein, human
0
Voltage-Gated Sodium Channel beta-1 Subunit
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-56Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL047678
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL152201
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL138103
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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