Large cell neuroendocrine carcinoma arising from the anterior mediastinum.
end of life decisions (palliative care)
endocrine cancer
radiology
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
25 May 2021
25 May 2021
Historique:
entrez:
26
5
2021
pubmed:
27
5
2021
medline:
28
5
2021
Statut:
epublish
Résumé
Anterior mediastinal large cell neuroendocrine carcinomas (LCNECs) are extremely rare, extremely aggressive malignancies that carry a dismal prognosis. We discuss a woman aged 60 years who presented with a 2-month history of recurrent severe constant epigastric pain. Abdominal examination revealed massive hepatomegaly and a CT scan of the liver confirmed coarse liver lesions. Histology from a liver biopsy was consistent with a large cell (non-small cell) neuroendocrine carcinoma. A CT scan of the chest showed a large anterior mediastinal mass unrelated to the lung, suggesting that the anterior mediastinum was the primary origin of the tumour. The patient was planned to receive platinum/etoposide chemotherapy for a metastatic mediastinal large cell neuroendocrine carcinoma. Unfortunately, her health deteriorated, and she was unfit to undergo any further treatment. She was treated palliatively and died 2 months after the diagnosis.
Identifiants
pubmed: 34035017
pii: 14/5/e240453
doi: 10.1136/bcr-2020-240453
pmc: PMC8154970
pii:
doi:
Substances chimiques
Etoposide
6PLQ3CP4P3
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Transl Lung Cancer Res. 2020 Oct;9(5):2233-2244
pubmed: 33209646
J Thorac Dis. 2017 Nov;9(Suppl 15):S1448-S1457
pubmed: 29201448
Cancer. 2008 Jul 1;113(1):5-21
pubmed: 18473355
Nihon Kokyuki Gakkai Zasshi. 2001 Sep;39(9):705-9
pubmed: 11729693
Nat Commun. 2018 Mar 13;9(1):1048
pubmed: 29535388
Virchows Arch. 2021 Jan;478(1):5-19
pubmed: 33474631
Transl Lung Cancer Res. 2019 Dec;8(Suppl 4):S430-S434
pubmed: 32038931
J Thorac Oncol. 2008 Feb;3(2):187-9
pubmed: 18303442
J Thorac Oncol. 2015 Sep;10(9):1243-1260
pubmed: 26291008
Endocr Relat Cancer. 2020 Nov;27(11):R417-R432
pubmed: 33032264
Transl Lung Cancer Res. 2017 Oct;6(5):513-529
pubmed: 29114468
Ann Thorac Surg. 2011 May;91(5):1618-20
pubmed: 21524479
Intern Med. 2019 Feb 15;58(4):563-568
pubmed: 30333385
J Thorac Oncol. 2011 Feb;6(2):244-85
pubmed: 21252716
Pancreas. 2013 May;42(4):557-77
pubmed: 23591432
Pathologe. 2016 Sep;37(5):434-40
pubmed: 27507161
Gen Thorac Cardiovasc Surg. 2013 Sep;61(9):542-5
pubmed: 23011520
Ann Diagn Pathol. 2018 Dec;37:30-34
pubmed: 30236546