INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer.
Animals
Antineoplastic Agents
/ pharmacology
Breast
/ pathology
Breast Neoplasms
/ drug therapy
Carcinogenesis
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Class I Phosphatidylinositol 3-Kinases
/ genetics
Endosomes
/ metabolism
Female
Gene Expression Profiling
Humans
Lysosomes
/ metabolism
Mice
Mutation
Phosphatidylinositol Phosphates
/ metabolism
Phosphoric Monoester Hydrolases
/ antagonists & inhibitors
Proteolysis
/ drug effects
Proteomics
Thiazoles
/ pharmacology
Tissue Array Analysis
Wnt Signaling Pathway
/ drug effects
Xenograft Model Antitumor Assays
rab GTP-Binding Proteins
/ metabolism
rab7 GTP-Binding Proteins
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
25 05 2021
25 05 2021
Historique:
received:
06
10
2020
accepted:
16
04
2021
entrez:
26
5
2021
pubmed:
27
5
2021
medline:
10
6
2021
Statut:
epublish
Résumé
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P
Identifiants
pubmed: 34035258
doi: 10.1038/s41467-021-23241-6
pii: 10.1038/s41467-021-23241-6
pmc: PMC8149851
doi:
Substances chimiques
Antineoplastic Agents
0
Phosphatidylinositol Phosphates
0
Thiazoles
0
phosphatidylinositol 3,4-diphosphate
0
phosphatidylinositol 3-phosphate
0
rab7 GTP-Binding Proteins
0
rab7 GTP-binding proteins, human
0
rab7 GTP-binding proteins, mouse
0
Alpelisib
08W5N2C97Q
Class I Phosphatidylinositol 3-Kinases
EC 2.7.1.137
PIK3CA protein, human
EC 2.7.1.137
Phosphoric Monoester Hydrolases
EC 3.1.3.2
phosphatidylinositol-3,4-bisphosphate 4-phosphatase
EC 3.1.3.66
rab GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3140Références
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