Biocompatibility of intraocular liquid tamponade agents: an update.
Journal
Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
01
03
2021
accepted:
05
05
2021
revised:
28
04
2021
pubmed:
27
5
2021
medline:
26
10
2021
entrez:
26
5
2021
Statut:
ppublish
Résumé
Intraocular liquids tamponade agents, such as perfluorocarbon liquids (PFCLs), semifluorinated alkanes (SFAs), silicone oils (SOs) and heavy silicone oils (HSOs), are a crucial intraoperative and/or postoperative tool in vitreoretinal surgery, in particular for the management of complex vitreoretinal diseases. However, their use is not without complications, which are potentially severe. Consequently, a growing interest has been devoted to the biocompatibility of these compounds and the adequacy of current regulations that should guarantee their safety. Obviously, an updated knowledge on research findings and potential risks associated to the use of intraocular liquid compounds is essential, not only for vitreoretinal surgeons, but also for any ophthalmologist involved in the management of patients receiving intraocular liquid tamponades. In light of this, the review provides a comprehensive characterisation of intraocular liquid tamponades, in terms of physical and chemical properties, current clinical use and possible complications. Moreover, this review focuses on the safety profile of these compounds, summarising the existing regulation and the available evidence on their biocompatibility. 摘要: 眼内液体填充剂, 如全氟化碳液体 (PFCLs) 、半氟化烷烃 (SFAs) 、硅油 (SOs) 和重硅油 (HSOs), 是玻璃体视网膜手术中及术后重要的玻璃体填充物, 对于复杂的玻璃体视网膜疾病的治疗尤其重要。然而, 这些填充剂可产生甚至严重的并发症。因此, 人们越来越关注这些化合物的生物相容性以及现行法规是否足以保证其使用的安全性。显然, 不仅对玻璃体视网膜疾病的外科医生来说, 或是对任何参与眼内液体填充患者治疗的眼科医生来说, 对眼内液体填充剂的研究结果和潜在风险有最新的认识和了解是必不可少的。有鉴于此, 本文就眼内液体填充剂的理化性质、临床应用现状及可能产生的并发症作一综述。此外, 本文还对这些填充剂的安全性进行了汇总, 并总结了有关其生物相容性的现有法规和现有证据。.
Autres résumés
Type: Publisher
(cze)
摘要: 眼内液体填充剂, 如全氟化碳液体 (PFCLs) 、半氟化烷烃 (SFAs) 、硅油 (SOs) 和重硅油 (HSOs), 是玻璃体视网膜手术中及术后重要的玻璃体填充物, 对于复杂的玻璃体视网膜疾病的治疗尤其重要。然而, 这些填充剂可产生甚至严重的并发症。因此, 人们越来越关注这些化合物的生物相容性以及现行法规是否足以保证其使用的安全性。显然, 不仅对玻璃体视网膜疾病的外科医生来说, 或是对任何参与眼内液体填充患者治疗的眼科医生来说, 对眼内液体填充剂的研究结果和潜在风险有最新的认识和了解是必不可少的。有鉴于此, 本文就眼内液体填充剂的理化性质、临床应用现状及可能产生的并发症作一综述。此外, 本文还对这些填充剂的安全性进行了汇总, 并总结了有关其生物相容性的现有法规和现有证据。.
Identifiants
pubmed: 34035489
doi: 10.1038/s41433-021-01596-w
pii: 10.1038/s41433-021-01596-w
pmc: PMC8452761
doi:
Substances chimiques
Fluorocarbons
0
Silicone Oils
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2699-2713Informations de copyright
© 2021. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.
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