Association of plasma VEGF levels and the antidepressant effects of ketamine in patients with depression.
depression
ketamine
plasma
vascular endothelial growth factor
Journal
Therapeutic advances in psychopharmacology
ISSN: 2045-1253
Titre abrégé: Ther Adv Psychopharmacol
Pays: England
ID NLM: 101555693
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
10
2020
accepted:
13
04
2021
entrez:
26
5
2021
pubmed:
27
5
2021
medline:
27
5
2021
Statut:
epublish
Résumé
Growing evidence suggests that vascular endothelial growth factor (VEGF) may be involved in the neuronal mechanisms underlying both depression aetiology and the response to ketamine treatments. The aim of this study was to examine whether changes in plasma VEGF levels are associated with the antidepressant effects of repeated ketamine infusions in patients with depression. Ninety-six patients with depression were enrolled and received six ketamine infusions during a 12-day period. Depressive symptom severity and plasma VEGF levels were measured by the Montgomery-Åsberg Depression Rating Scale (MADRS) and an enzyme-linked immunosorbent assay (ELISA) respectively, at baseline, 13 days and 26 days. Despite a significant improvement in MADRS scores after patients received six ketamine infusions ( This study indicated that VEGF may not be a potential predictor of antidepressant response to repeated intravenous administration of ketamine in patients with depression.
Identifiants
pubmed: 34035893
doi: 10.1177/20451253211014320
pii: 10.1177_20451253211014320
pmc: PMC8132091
doi:
Types de publication
Journal Article
Langues
eng
Pagination
20451253211014320Informations de copyright
© The Author(s), 2021.
Déclaration de conflit d'intérêts
Conflict of interest statement: The authors declare that there is no conflict of interest.
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