Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial.

Anti-Bacterial Agents / therapeutic use Azithromycin / pharmacology Child, Preschool Drug Resistance, Bacterial / genetics Humans Macrolides / pharmacology Mass Drug Administration
Niger antibiotic resistance azithromycin gut resistome mass drug distribution preschool children

Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213

Informations de publication

Date de publication:
05 10 2021
Historique:
received: 01 03 2021
pubmed: 27 5 2021
medline: 21 10 2021
entrez: 26 5 2021
Statut: ppublish

Résumé

We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs. NCT02047981.

Identifiants

DOI: 10.1093/cid/ciab485 PMID: 34037753 PMC: PMC8492121
pubmed: 34037753
pii: 6284341
doi: 10.1093/cid/ciab485
pmc: PMC8492121
doi:

Substances chimiques

Anti-Bacterial Agents 0
Macrolides 0
Azithromycin 83905-01-5

Banques de données

ClinicalTrials.gov
['NCT02047981']

Types de publication

Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1292-1295

Subventions

Organisme : NEI NIH HHS
ID : K08 EY026986
Pays : United States
Organisme : Bill and Melinda Gates Foundation
Organisme : Peierls Foundation
Organisme : Research to Prevent Blindness Career Development Award
Organisme : Research to Prevent Blindness

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

Références

N Engl J Med. 2018 Apr 26;378(17):1583-1592
pubmed: 29694816
N Engl J Med. 2019 Jun 06;380(23):2207-2214
pubmed: 31167050
Nat Commun. 2018 Mar 21;9(1):1179
pubmed: 29563494
Nucleic Acids Res. 2017 Jan 4;45(D1):D574-D580
pubmed: 27899569
Trop Med Infect Dis. 2021 Jan 16;6(1):
pubmed: 33467065
Microbiol Mol Biol Rev. 2015 Mar;79(1):101-16
pubmed: 25652543
PLoS One. 2012;7(1):e29407
pubmed: 22272234
N Engl J Med. 2019 Jun 06;380(23):2271-2273
pubmed: 31167060
Scand J Public Health. 2016 Feb;44(1):2-5
pubmed: 26392424
Nat Med. 2019 Sep;25(9):1370-1376
pubmed: 31406349
Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29063-29068
pubmed: 33139558
N Engl J Med. 2020 Nov 12;383(20):1941-1950
pubmed: 33176084

Auteurs

Ahmed M Arzika (AM)

The Carter Center, Niamey, Niger.

Ramatou Maliki (R)

The Carter Center, Niamey, Niger.

Amza Abdou (A)

Ministry of Health, Niamey, Niger.
Programme National de Santé Oculaire, Niamey, Niger.

Alio K Mankara (AK)

The Carter Center, Niamey, Niger.

Abdoul N Harouna (AN)

The Carter Center, Niamey, Niger.

Catherine Cook (C)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.

Armin Hinterwirth (A)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.

Lee Worden (L)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.

Lina Zhong (L)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.

Cindi Chen (C)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.

Kevin Ruder (K)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.

Zhaoxia Zhou (Z)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.

Elodie Lebas (E)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.

Kieran S O'Brien (KS)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.

Catherine E Oldenburg (CE)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Department of Ophthalmology, University of California San Francisco, San Francisco, California, USA.
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.

Victoria Le (V)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.

Benjamin F Arnold (BF)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.

Travis C Porco (TC)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Department of Ophthalmology, University of California San Francisco, San Francisco, California, USA.
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.

Jeremy D Keenan (JD)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Department of Ophthalmology, University of California San Francisco, San Francisco, California, USA.
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.

Thomas M Lietman (TM)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Department of Ophthalmology, University of California San Francisco, San Francisco, California, USA.
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Institute for Global Health Sciences, University of California San Francisco, San Francisco, California, USA.

Thuy Doan (T)

Francis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Department of Ophthalmology, University of California San Francisco, San Francisco, California, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Gut Resistome of Preschool Children After...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Érythromycine › Azithromycine › Gut Resistome of Preschool Children After...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Gut Resistome of Preschool Children After...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Gut Resistome of Preschool Children After...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gut Resistome of Preschool Children After...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Macrolides › Gut Resistome of Preschool Children After...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Contrôle des maladies transmissibles › Administration massive de médicament › Gut Resistome of Preschool Children After...