YbeY is required for ribosome small subunit assembly and tRNA processing in human mitochondria.
Amino Acid Sequence
Cell Survival
/ genetics
Gene Knockout Techniques
HEK293 Cells
Humans
Immunohistochemistry
Mass Spectrometry
Mitochondria
/ enzymology
Mitochondrial Proteins
/ metabolism
Mitochondrial Ribosomes
/ metabolism
Protein Biosynthesis
/ genetics
RNA Processing, Post-Transcriptional
/ genetics
RNA, Transfer
/ metabolism
Ribonucleases
/ metabolism
Ribosome Subunits, Small
/ metabolism
Sequence Alignment
Journal
Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011
Informations de publication
Date de publication:
04 06 2021
04 06 2021
Historique:
accepted:
06
05
2021
revised:
20
04
2021
received:
10
12
2019
pubmed:
27
5
2021
medline:
29
6
2021
entrez:
26
5
2021
Statut:
ppublish
Résumé
Mitochondria contain their own translation apparatus which enables them to produce the polypeptides encoded in their genome. The mitochondrially-encoded RNA components of the mitochondrial ribosome require various post-transcriptional processing steps. Additional protein factors are required to facilitate the biogenesis of the functional mitoribosome. We have characterized a mitochondrially-localized protein, YbeY, which interacts with the assembling mitoribosome through the small subunit. Loss of YbeY leads to a severe reduction in mitochondrial translation and a loss of cell viability, associated with less accurate mitochondrial tRNASer(AGY) processing from the primary transcript and a defect in the maturation of the mitoribosomal small subunit. Our results suggest that YbeY performs a dual, likely independent, function in mitochondria being involved in precursor RNA processing and mitoribosome biogenesis. Issue Section: Nucleic Acid Enzymes.
Identifiants
pubmed: 34037799
pii: 6284182
doi: 10.1093/nar/gkab404
pmc: PMC8191802
doi:
Substances chimiques
Mitochondrial Proteins
0
RNA, Transfer
9014-25-9
Ribonucleases
EC 3.1.-
YBEY protein, human
EC 3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5798-5812Subventions
Organisme : Medical Research Council
ID : MC_UU_00015/4
Pays : United Kingdom
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.
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