Burden of venous thromboembolism in patients with pancreatic cancer.
Direct oral anticoagulant
Low-molecular weight heparin
Multi-language mobile application
Pancreatic cancer
Risk-assessment models
Thromboprophylaxis
Venous thromboembolism
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
21 May 2021
21 May 2021
Historique:
received:
24
01
2021
revised:
28
02
2021
accepted:
22
04
2021
entrez:
27
5
2021
pubmed:
28
5
2021
medline:
29
5
2021
Statut:
ppublish
Résumé
Pancreatic cancer (PC) is a devastating malignancy with fewer than 10% of patients being alive at 5 years after diagnosis. Venous thromboembolism (VTE) occurs in approximatively 20% of patients with PC, resulting in increased morbidity, mortality and significant health care costs. The management of VTE is particularly challenging in these frail patients. Adequate selection of the most appropriate anticoagulant for each individual patient according to the current international guidelines is warranted for overcoming treatment challenges. The International Initiative on Thrombosis and Cancer multi-language web-based mobile application (downloadable for free at www.itaccme.com) has been developed to help clinicians in decision making in the most complex situations. In this narrative review, we will discuss the contemporary epidemiology and burden of VTE in PC patients, the performances and limitations of current risk assessment models to predict the risk of VTE, as well as evidence from recent clinical trials for the primary prophylaxis and treatment of cancer-associated VTE that support up-dated clinical practice guidelines.
Identifiants
pubmed: 34040325
doi: 10.3748/wjg.v27.i19.2325
pmc: PMC8130043
doi:
Substances chimiques
Anticoagulants
0
Heparin, Low-Molecular-Weight
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2325-2340Informations de copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The author declare she has no conflict of interest relevant to the content of this paper to disclose.
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