Immunological Responses to Envenomation.
Irukandji syndrome
adaptive immunity
detoxification
immunopathology
innate immunity
systemic inflammation
venom
venom allergy
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
01
2021
accepted:
01
04
2021
entrez:
27
5
2021
pubmed:
28
5
2021
medline:
15
10
2021
Statut:
epublish
Résumé
Venoms are complex mixtures of toxic compounds delivered by bite or sting. In humans, the consequences of envenomation range from self-limiting to lethal. Critical host defence against envenomation comprises innate and adaptive immune strategies targeted towards venom detection, neutralisation, detoxification, and symptom resolution. In some instances, venoms mediate immune dysregulation that contributes to symptom severity. This review details the involvement of immune cell subtypes and mediators, particularly of the dermis, in host resistance and venom-induced immunopathology. We further discuss established venom-associated immunopathology, including allergy and systemic inflammation, and investigate Irukandji syndrome as a potential systemic inflammatory response. Finally, this review characterises venom-derived compounds as a source of immune modulating drugs for treatment of disease.
Identifiants
pubmed: 34040609
doi: 10.3389/fimmu.2021.661082
pmc: PMC8141633
doi:
Substances chimiques
Venoms
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
661082Informations de copyright
Copyright © 2021 Ryan, Seymour, Loukas, Lopez, Ikonomopoulou and Miles.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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