Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Attenuates the Development of Angiotensin II-Mediated Abdominal Aortic Aneurysm in Obese
angiotensin II
aortic aneurysm
inflammation
macrophages
mouse
natural killer T cells
obesity
α-galactosylceramide
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
01
2021
accepted:
13
04
2021
entrez:
27
5
2021
pubmed:
28
5
2021
medline:
28
5
2021
Statut:
epublish
Résumé
The infiltration and activation of macrophages as well as lymphocytes within the aorta contribute to the pathogenesis of abdominal aortic aneurysm (AAA). Invariant natural killer T (iNKT) cells are unique subset of T lymphocytes and have a crucial role in atherogenesis. However, it remains unclear whether iNKT cells also impact on the development of AAA.
Identifiants
pubmed: 34041282
doi: 10.3389/fcvm.2021.659418
pmc: PMC8141584
doi:
Types de publication
Journal Article
Langues
eng
Pagination
659418Informations de copyright
Copyright © 2021 Saito, Ishimori, Tokuhara, Homma, Nishikawa, Iwabuchi and Tsutsui.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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