Estradiol induces allosteric coupling and partitioning of sex-hormone-binding globulin monomers among conformational states.

Biochemistry Endocrinology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
25 Jun 2021
Historique:
received: 11 01 2021
revised: 13 02 2021
accepted: 07 04 2021
entrez: 27 5 2021
pubmed: 28 5 2021
medline: 28 5 2021
Statut: epublish

Résumé

Sex-hormone-binding globulin (SHBG) regulates the transport and bioavailability of estradiol. The dynamics of estradiol's binding to SHBG are incompletely understood, although it is believed that estradiol binds to each monomer of SHBG dimer with identical affinity (K

Identifiants

DOI: 10.1016/j.isci.2021.102414 PMID: 34041454 PMC: PMC8144348
pubmed: 34041454
doi: 10.1016/j.isci.2021.102414
pii: S2589-0042(21)00382-5
pmc: PMC8144348
doi:

Types de publication

Journal Article

Langues

eng

Pagination

102414

Subventions

Organisme : NIGMS NIH HHS
ID : R15 GM128102
Pays : United States
Organisme : NIGMS NIH HHS
ID : R15 GM129715
Pays : United States
Organisme : NIGMS NIH HHS
ID : R15 GM144870
Pays : United States

Informations de copyright

© 2021 The Author(s).

Déclaration de conflit d'intérêts

Dr. Jasuja reports receiving NIH grant funding, equity interest in FPT, LLC, and participation in a patent on a method to calculate free sex hormone concentration. These conflicts are overseen by and managed according to policies of the Office of Industry Interaction of the Mass General Brigham Health Care System. Dr. Bhasin reports receiving research grant funding, unrelated to the research reported in this manuscript, from NIA, NINR, NICHD, AbbVie, Metro International Biotechnology, Alivegen, Transition Therapeutics, and FPT; receiving consultant fees from OPKO; participation in a patent to calculate free sex hormones; and holding equity interest in FPT, LLC. These conflicts are overseen by and managed according to policies of the Office of Industry Interaction of the Mass General Brigham Health Care System. The other authors have nothing to disclose.

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Auteurs

Ravi Jasuja (R)

Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Function Promoting Therapies, Waltham, MA, USA.

Daniel Spencer (D)

Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Abhilash Jayaraj (A)

Supercomputing Facility for Bioinformatics and Computational Biology, Indian Institute of Technology, New Delhi, 110 016 India.
Departments of Chemistry, Molecular Biology, and Biochemistry and Molecular Biophysics Program, Wesleyan University, Middletown, CT, USA.

Liming Peng (L)

Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Meenakshi Krishna (M)

Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Brian Lawney (B)

Center for Cancer Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Function Promoting Therapies, Waltham, MA, USA.

Priyank Patel (P)

Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Bhyravabhotla Jayaram (B)

Supercomputing Facility for Bioinformatics and Computational Biology, Indian Institute of Technology, New Delhi, 110 016 India.

Kelly M Thayer (KM)

Departments of Chemistry, Molecular Biology, and Biochemistry and Molecular Biophysics Program, Wesleyan University, Middletown, CT, USA.

David L Beveridge (DL)

Departments of Chemistry, Molecular Biology, and Biochemistry and Molecular Biophysics Program, Wesleyan University, Middletown, CT, USA.

Shalender Bhasin (S)

Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Classifications MeSH