The effect of grape interventions on cognitive and mental performance in healthy participants and those with mild cognitive impairment: a systematic review of randomized controlled trials.
Vitis
cognition
grape
memory
mood
Journal
Nutrition reviews
ISSN: 1753-4887
Titre abrégé: Nutr Rev
Pays: United States
ID NLM: 0376405
Informations de publication
Date de publication:
10 Feb 2022
10 Feb 2022
Historique:
received:
01
10
2020
revised:
24
12
2020
accepted:
13
03
2021
pubmed:
28
5
2021
medline:
31
3
2022
entrez:
27
5
2021
Statut:
ppublish
Résumé
The prevalence of cognitive and mental health disorders are growing, and existing drug therapies do not treat the underlying cause. Grapes are a flavonoid-rich soft fruit and may therefore be beneficial to cognitive and mental health. To systematically review evidence from randomized controlled trials investigating the acute and chronic effects of grape interventions on measures of cognition and mood in healthy participants and those with mild cognitive impairment. MEDLINE, The Cochrane Library and EMBASE were searched. Eight studies met the inclusion criteria: one considered acute interventions, 6 assessed chronic effects, and one assessed acute and chronic effects of grapes. The chronic studies found improvements in some cognitive domains (eg, memory, motor skills, or executive function). Acute studies found no consistent effect on memory but saw improvements in reaction time. Differences in study design, dosages, and outcome tests hindered between-study comparison. Even so, the results across studies show that grapes can enhance some aspects of cognition, after both acute and chronic interventions. PROSPERO registration no. CRD42020193062.
Identifiants
pubmed: 34041549
pii: 6285577
doi: 10.1093/nutrit/nuab025
pmc: PMC8829676
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
367-380Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the International Life Sciences Institute.
Références
Dialogues Clin Neurosci. 2019 Sep;21(3):227-237
pubmed: 31749647
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
Genes Nutr. 2009 Dec;4(4):227-42
pubmed: 19680703
Crit Rev Food Sci Nutr. 2021;61(4):566-576
pubmed: 32208848
PLoS One. 2017 Nov 15;12(11):e0188173
pubmed: 29141041
Nutr Neurosci. 2022 Jan;25(1):54-63
pubmed: 31942838
Am J Clin Nutr. 2016 Mar;103(3):775-83
pubmed: 26864371
BMJ. 2011 Oct 18;343:d5928
pubmed: 22008217
J Gerontol A Biol Sci Med Sci. 2019 Jun 18;74(7):984-995
pubmed: 30941401
J Gerontol A Biol Sci Med Sci. 2019 Jun 18;74(7):996-1007
pubmed: 30032176
Brain Behav Immun. 2020 Mar;85:96-105
pubmed: 30999017
Eur J Nutr. 2017 Dec;56(8):2621-2631
pubmed: 28429081
Nutrients. 2020 Jan 01;12(1):
pubmed: 31906271
Br J Nutr. 2010 Oct;104 Suppl 3:S40-7
pubmed: 20955649
Nutrients. 2019 Nov 06;11(11):
pubmed: 31698695
J Agric Food Chem. 2012 Jun 13;60(23):5736-42
pubmed: 22468945
Front Pharmacol. 2017 Oct 31;8:776
pubmed: 29163162
Br J Nutr. 2010 Mar;103(5):730-4
pubmed: 20028599
Exp Gerontol. 2017 Jan;87(Pt A):121-128
pubmed: 27856335