Does Cardiopulmonary Testing Help Predict Long-Term Survival After Esophagectomy?
Journal
Annals of surgical oncology
ISSN: 1534-4681
Titre abrégé: Ann Surg Oncol
Pays: United States
ID NLM: 9420840
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
17
03
2021
accepted:
21
04
2021
pubmed:
28
5
2021
medline:
21
10
2021
entrez:
27
5
2021
Statut:
ppublish
Résumé
Esophagectomy is associated with a high rate of morbidity and mortality. Preoperative cardiopulmonary fitness has been correlated with outcomes of major surgery. Variables derived from cardiopulmonary exercise testing (CPET) have been associated with postoperative outcomes. It is unclear whether preoperative cardiorespiratory fitness of patients undergoing esophagectomy is associated with long-term survival. This study aimed to evaluate whether any of the CPET variables routinely derived from patients with esophageal cancer may aid in predicting long-term survival after esophagectomy. Patients undergoing CPET followed by trans-thoracic esophagectomy for esophageal cancer with curative intent between January 2013 and January 2017 from single high-volume center were retrospectively analyzed. The relationship between predictive co-variables, including CPET variables and survival, was studied with a Cox proportional hazard model. Receiver operation curve (ROC) analysis was performed to find cutoff values for CPET variables predictive of 3-year survival. The study analyzed 313 patients. The ventilatory equivalent for carbon dioxide (VE/VCO A high VE/VCO
Sections du résumé
BACKGROUND
BACKGROUND
Esophagectomy is associated with a high rate of morbidity and mortality. Preoperative cardiopulmonary fitness has been correlated with outcomes of major surgery. Variables derived from cardiopulmonary exercise testing (CPET) have been associated with postoperative outcomes. It is unclear whether preoperative cardiorespiratory fitness of patients undergoing esophagectomy is associated with long-term survival. This study aimed to evaluate whether any of the CPET variables routinely derived from patients with esophageal cancer may aid in predicting long-term survival after esophagectomy.
METHODS
METHODS
Patients undergoing CPET followed by trans-thoracic esophagectomy for esophageal cancer with curative intent between January 2013 and January 2017 from single high-volume center were retrospectively analyzed. The relationship between predictive co-variables, including CPET variables and survival, was studied with a Cox proportional hazard model. Receiver operation curve (ROC) analysis was performed to find cutoff values for CPET variables predictive of 3-year survival.
RESULTS
RESULTS
The study analyzed 313 patients. The ventilatory equivalent for carbon dioxide (VE/VCO
CONCLUSIONS
CONCLUSIONS
A high VE/VCO
Identifiants
pubmed: 34041625
doi: 10.1245/s10434-021-10136-5
pii: 10.1245/s10434-021-10136-5
pmc: PMC8519940
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7291-7297Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. The Author(s).
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