Animal blood in translational research: How to adjust animal blood viscosity to the human standard.
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
03
04
2021
accepted:
27
04
2021
entrez:
27
5
2021
pubmed:
28
5
2021
medline:
21
1
2022
Statut:
ppublish
Résumé
Animal blood is used in mock circulations or in forensic bloodstain pattern analysis. Blood viscosity is important in these settings as it determines the driving pressure through biomedical devices and the shape of the bloodstain. However, animal blood can never exactly mimic human blood due to erythrocyte properties differing among species. This results in the species-specific shear thinning behavior of blood suspensions, and it is therefore not enough to adjust the hematocrit of an animal blood sample to mimic the behavior of human blood over the entire range of shear rates that are present in the body. In order to optimize experiments that require animal blood, we need models to adapt the blood samples. We here offer mathematical models derived for each species using a multi linear regression approach to describe the influence of shear rate, hematocrit, and temperature on blood viscosity. Results show that pig blood cannot be recommended for experiments at low flow conditions (<200 s
Identifiants
pubmed: 34042285
doi: 10.14814/phy2.14880
pmc: PMC8157792
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14880Informations de copyright
© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
Références
J Biomech Eng. 2011 Oct;133(10):101002
pubmed: 22070327
Bioengineering (Basel). 2021 Mar 02;8(3):
pubmed: 33801555
Forensic Sci Int. 2020 Jun;311:110268
pubmed: 32283501
Microvasc Res. 1997 May;53(3):201-10
pubmed: 9211398
Am J Physiol. 1968 Apr;214(4):913-8
pubmed: 5642957
J Trauma. 2003 Sep;55(3):407-12
pubmed: 14501879
Microvasc Res. 1976 Mar;11(2):133-46
pubmed: 1272076
J Vasc Res. 2006;43(3):251-69
pubmed: 16491020
Forensic Sci Int. 2016 Sep;266:178-184
pubmed: 27289034
Artif Organs. 2015 Mar;39(3):237-48
pubmed: 25180887
J Biomech Eng. 2012 Aug;134(8):081002
pubmed: 22938355
Biorheology. 1976 Jun;13(3):201-10
pubmed: 953256
Anesth Analg. 2000 Sep;91(3):539-45
pubmed: 10960372
Biomech Model Mechanobiol. 2012 Jan;11(1-2):231-44
pubmed: 21465260
J Biomech Eng. 2021 May 1;143(5):
pubmed: 33462588
J Forensic Sci. 2013 Sep;58(5):1289-96
pubmed: 23865610
Am J Physiol. 1997 Dec;273(6):H2604-12
pubmed: 9435593
Sci Rep. 2020 Sep 23;10(1):15492
pubmed: 32968087
Multivariate Behav Res. 1991 Jul 1;26(3):499-510
pubmed: 26776715
Sci Rep. 2015 Jun 26;5:11631
pubmed: 26113000
J Am Soc Nephrol. 2002 Jan;13 Suppl 1:S53-61
pubmed: 11792763
Exp Physiol. 2003 May;88(3):431-40
pubmed: 12719768
Sci Justice. 1996 Jul-Sep;36(3):153-60
pubmed: 8789932
J Appl Physiol. 1970 Feb;28(2):172-7
pubmed: 5413303
Curr Treat Options Neurol. 2012 Dec;14(6):541-8
pubmed: 23007950