A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo.
GC-pyrolysis-IRMS
bone turnover
collagen synthesis
deuterium oxide
stable isotopes
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
18
02
2021
accepted:
21
02
2021
entrez:
27
5
2021
pubmed:
28
5
2021
medline:
21
1
2022
Statut:
ppublish
Résumé
The development of safe and practical strategies to prevent weakening of bone tissue is vital, yet attempts to achieve this have been hindered by a lack of understanding of the short-term (days-weeks) physiology of bone collagen turnover. To address this, we have developed a method to quantify bone collagen synthesis in vivo, using deuterium oxide (D
Identifiants
pubmed: 34042295
doi: 10.14814/phy2.14799
pmc: PMC8157767
doi:
Substances chimiques
Radiation-Protective Agents
0
Collagen
9007-34-5
Deuterium Oxide
J65BV539M3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14799Subventions
Organisme : NIH HHS
ID : P40 OD021331
Pays : United States
Organisme : Medical Research Council
ID : MR/P021220/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
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