An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice.
Analgesics, Opioid
/ therapeutic use
Animals
Animals, Genetically Modified
Behavior, Animal
/ drug effects
Calcium Signaling
Disease Models, Animal
Drug Tolerance
Female
GABAergic Neurons
/ metabolism
Glutamic Acid
/ metabolism
Hypothalamic Area, Lateral
/ drug effects
Male
Mice, Inbred C57BL
Microscopy, Fluorescence
Morphine
/ pharmacology
Neural Pathways
/ metabolism
Neuroanatomical Tract-Tracing Techniques
Nociception
/ drug effects
Optogenetics
Pain
/ metabolism
Parvalbumins
/ genetics
calcium imaging
chemogenetics
lateral hypothalamus
mouse
neuroscience
nociception
optogenetics
pain
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
27 05 2021
27 05 2021
Historique:
received:
11
01
2021
accepted:
12
05
2021
entrez:
27
5
2021
pubmed:
28
5
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Understanding how neuronal circuits control nociceptive processing will advance the search for novel analgesics. We use functional imaging to demonstrate that lateral hypothalamic parvalbumin-positive (LH
Identifiants
pubmed: 34042586
doi: 10.7554/eLife.66446
pii: 66446
pmc: PMC8159376
doi:
pii:
Substances chimiques
Analgesics, Opioid
0
Parvalbumins
0
Glutamic Acid
3KX376GY7L
Morphine
76I7G6D29C
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103808
Pays : United States
Déclaration de conflit d'intérêts
JS, MA, SS, CB, LE, AE, AR, GL, YA No competing interests declared
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