Marine microbial L-glutaminase: from pharmaceutical to food industry.
Fermentation
Food industry
L-glutaminase
Marine microorganisms
Therapeutic application
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
23
03
2021
accepted:
16
05
2021
revised:
11
05
2021
pubmed:
28
5
2021
medline:
16
6
2021
entrez:
27
5
2021
Statut:
ppublish
Résumé
Deamination of L-glutamine to glutamic acid with the concomitant release of ammonia by the activity of L-glutaminase (L-glutamine amidohydrolase EC 3.5.1.2) is a unique reaction that also finds potential applications in different sectors ranging from therapeutics to food industry. Owing to its cost-effectiveness, rapidity, and compatibility with downstream processes, microbial production of L-glutaminase is preferred over the production by other sources. Marine microorganisms including bacteria, yeasts, and moulds have manifested remarkable capacity to produce L-glutaminase and, therefore, are considered as prospective candidates for large-scale production of this enzyme. The main focus of this article is to provide an overview of L-glutaminase producing marine microorganisms, to discuss strategies used for the lab- and large-scale production of these enzyme and to review the application of L-glutaminase from marine sources so that the future prospects can be understood. KEY POINTS: • L-glutaminase has potential applications in different sectors ranging from therapeutics to food industry • Marine microorganisms are considered as prospective candidates for large-scale production of L-glutaminase • Marine microbial L-glutaminase have great potential in therapeutics and in the food industry.
Identifiants
pubmed: 34043082
doi: 10.1007/s00253-021-11356-1
pii: 10.1007/s00253-021-11356-1
doi:
Substances chimiques
Pharmaceutical Preparations
0
Glutamine
0RH81L854J
Glutaminase
EC 3.5.1.2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4453-4466Références
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