Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation.
Estimated glomerular filtration rate
Mendelian randomization analysis
Renal function
Venous thromboembolism
Journal
Journal of thrombosis and thrombolysis
ISSN: 1573-742X
Titre abrégé: J Thromb Thrombolysis
Pays: Netherlands
ID NLM: 9502018
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
accepted:
21
05
2021
pubmed:
28
5
2021
medline:
7
4
2022
entrez:
27
5
2021
Statut:
ppublish
Résumé
Whether renal function is causally associated with venous thromboembolism (VTE) is not yet fully elucidated. We conducted a two-sample Mendelian randomization (MR) study to determine the causal effect of renal function, measured as estimated glomerular filtration rate (eGFR), on VTE. Single-nucleotide polymorphisms associated with eGFR were selected as instrumental variables at the genome-wide significance level (p < 5 × 10
Identifiants
pubmed: 34043151
doi: 10.1007/s11239-021-02494-4
pii: 10.1007/s11239-021-02494-4
pmc: PMC8791872
doi:
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-50Subventions
Organisme : Forskningsrådet om Hälsa, Arbetsliv och Välfärd
ID : 2018-00123
Organisme : Vetenskapsrådet
ID : 2019-00977
Organisme : Hjärt-Lungfonden
ID : 20190247
Organisme : Stockholms Läns Landsting
ID : K2892-2016
Informations de copyright
© 2021. The Author(s).
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