Ginsenosides regulation of lysophosphatidylcholine profiles underlies the mechanism of Shengmai Yin in attenuating atherosclerosis.
Animals
Apolipoproteins E
/ genetics
Atherosclerosis
/ genetics
Cholesterol
/ blood
Cholesterol, Dietary
Cytokines
/ blood
Disease Models, Animal
Drug Combinations
Drugs, Chinese Herbal
/ pharmacology
Ginsenosides
/ isolation & purification
Lysophosphatidylcholines
/ blood
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Atherosclerosis
Ginsenosides
Lipidomics
Lysophosphatidylcholine
Metabolomics
Shengmai Yin
Journal
Journal of ethnopharmacology
ISSN: 1872-7573
Titre abrégé: J Ethnopharmacol
Pays: Ireland
ID NLM: 7903310
Informations de publication
Date de publication:
15 Sep 2021
15 Sep 2021
Historique:
received:
15
02
2021
revised:
13
05
2021
accepted:
19
05
2021
pubmed:
28
5
2021
medline:
24
11
2021
entrez:
27
5
2021
Statut:
ppublish
Résumé
The traditional Chinese medicine (TCM) preparation, Shengmai Yin (SMY), is widely applied in cardiovascular disease treatments. However, the pharmacological mechanism of its therapeutic effects has not been fully clarified. This study aimed to clearly define the efficacy and underlying mechanism of SMY and its active components in protecting against atherosclerosis. The pharmacological effects of SMY and its components were evaluated upon a mouse hypercholesteremia model induced by a high cholesterol diet (HCD) for 12 weeks and Apoe SMY and red ginseng crude extracts (GE) significantly decreased the serum cholesterol levels in hypercholesteremia mice and reduced the aortic root plaque areas and exerted antiatherogenic efficacy in Apoe Our findings revealed that ginsenosides from SMY exerted therapeutic effects on atherosclerosis by maintaining lipid homeostasis including cholesterol and lysoPCs.
Identifiants
pubmed: 34044080
pii: S0378-8741(21)00450-5
doi: 10.1016/j.jep.2021.114223
pii:
doi:
Substances chimiques
Apolipoproteins E
0
Cholesterol, Dietary
0
Cytokines
0
Drug Combinations
0
Drugs, Chinese Herbal
0
Ginsenosides
0
Lysophosphatidylcholines
0
fructus schizandrae, radix ginseng, radix ophiopogonis drug combination
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114223Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.