Modifications of polysaccharide-based biomaterials under structure-property relationship for biomedical applications.
applications
bioactivities
modification
polysaccharide
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
15 Aug 2021
15 Aug 2021
Historique:
received:
08
02
2021
revised:
13
04
2021
accepted:
17
04
2021
entrez:
28
5
2021
pubmed:
29
5
2021
medline:
16
10
2021
Statut:
ppublish
Résumé
Polysaccharides are well accepted biomaterials that have attracted considerable attention. Compared with other materials under research, polysaccharides show unique advantages: they are available in nature and are normally easily acquired, those acquired from nature show favorable immunogenicity, and are biodegradable and bioavailable. The bioactivity and possible applications are based on their chemical structure; however, naturally acquired polysaccharides sometimes have unwanted flaws that limit further applications. For this reason, carefully summarizing the possible modifications of polysaccharides to improve them is crucial. Structural modifications can not only provide polysaccharides with additional functional groups but also change their physicochemical properties. This review based on the structure-property relation summarizes the common chemical modifications of polysaccharides, the related bioactivity changes, possible functionalization methods, and major possible biomedical applications based on modified polysaccharides.
Identifiants
pubmed: 34044964
pii: S0144-8617(21)00484-7
doi: 10.1016/j.carbpol.2021.118097
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Polysaccharides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
118097Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.