Drug Delivery to the Bone Microenvironment Mediated by Exosomes: An Axiom or Enigma.
RANK-RANKL pathway
bone diseases
drug delivery
exosome-liposome hybrid
exosomes
nanosystems
Journal
International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
02
2021
accepted:
30
03
2021
entrez:
28
5
2021
pubmed:
29
5
2021
medline:
12
6
2021
Statut:
epublish
Résumé
The increasing incidence of bone-related disorders is causing a burden on the clinical scenario. Even though bone is one of the tissues that possess tremendous regenerative potential, certain bone anomalies need therapeutic intervention through appropriate delivery of a drug. Among several nanosystems and biologics that offer the potential to contribute towards bone healing, the exosomes from the class of extracellular vesicles are outstanding. Exosomes are extracellular nanovesicles that, apart from the various advantages, are standing out of the crowd for their ability to conduct cellular communication. The internal cargo of the exosomes is leading to its potential use in therapeutics. Exosomes are being unraveled in terms of the mechanism as well as application in targeting various diseases and tissues. Through this review, we have tried to understand and review all that is already established and the gap areas that still exist in utilizing them as drug delivery vehicles targeting the bone. The review highlights the potential of the exosomes towards their contribution to the drug delivery scenario in the bone microenvironment. A comparison of the pros and cons of exosomes with other prevalent drug delivery systems is also done. A section on the patents that have been generated so far from this field is included.
Identifiants
pubmed: 34045855
doi: 10.2147/IJN.S307843
pii: 307843
pmc: PMC8149288
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3509-3540Informations de copyright
© 2021 Samal et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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