A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Assessing Efficacy and Safety of a Novel Low-Dose Turmeric Extract Formulation in Healthy Adults with Chronic Knee Pain.
biomarkers
chronic pain
curcuminoids
knee joint
turmeric
visual analog scale
Journal
Clinical pharmacology : advances and applications
ISSN: 1179-1438
Titre abrégé: Clin Pharmacol
Pays: New Zealand
ID NLM: 101564865
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
02
2021
accepted:
24
03
2021
entrez:
28
5
2021
pubmed:
29
5
2021
medline:
29
5
2021
Statut:
epublish
Résumé
Knee pain causes functional limitations, eventually compromising the quality of life. We evaluated the efficacy of our water-dispersible turmeric formulation (60% natural curcuminoids, TurmXTRA 60N In this randomized, double-blind, placebo-controlled trial, subjects received either 250 mg WDTE60N capsule (150 mg curcuminoids; n = 53) or appearance-matched placebo capsule (n = 53) once daily for 90 days. Primary endpoint was change in pain score on the visual analogue scale (VAS) after 80-m fast-paced walk test. A total of 96 subjects completed the study. WDTE60N reduced VAS score from baseline (5.4 ± 0.9) to day 90 (3.8 ± 0.8) with greater mean reduction than placebo (-1.5 ± 0.7 vs -0.6 ± 0.8, WDTE60N 250 mg administered once daily for 3 months, alleviated knee pain, improved joint function in healthy subjects with chronic knee pain, was well tolerated and safe.
Sections du résumé
BACKGROUND
BACKGROUND
Knee pain causes functional limitations, eventually compromising the quality of life. We evaluated the efficacy of our water-dispersible turmeric formulation (60% natural curcuminoids, TurmXTRA 60N
METHODS
METHODS
In this randomized, double-blind, placebo-controlled trial, subjects received either 250 mg WDTE60N capsule (150 mg curcuminoids; n = 53) or appearance-matched placebo capsule (n = 53) once daily for 90 days. Primary endpoint was change in pain score on the visual analogue scale (VAS) after 80-m fast-paced walk test.
RESULTS
RESULTS
A total of 96 subjects completed the study. WDTE60N reduced VAS score from baseline (5.4 ± 0.9) to day 90 (3.8 ± 0.8) with greater mean reduction than placebo (-1.5 ± 0.7 vs -0.6 ± 0.8,
CONCLUSION
CONCLUSIONS
WDTE60N 250 mg administered once daily for 3 months, alleviated knee pain, improved joint function in healthy subjects with chronic knee pain, was well tolerated and safe.
Identifiants
pubmed: 34045905
doi: 10.2147/CPAA.S307464
pii: 307464
pmc: PMC8149286
doi:
Types de publication
Journal Article
Langues
eng
Pagination
91-100Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021 Thanawala et al.
Déclaration de conflit d'intérêts
Shefali Thanawala and Rajat Shah are employees of Inventia Healthcare Ltd. KrishnaRaju Venkata Alluri and Venkateswarlu Somepalli are employees of Laila Nutraceuticals. Prabakaran Desomayanandam and Arun Bhuvanendran are employees of In Vitro Research Solutions (iVRS) Pvt Ltd. The authors do not have any other conflicts of interest to declare.
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